Eukaryotic noncoding DNA sequences provide genes with an additional protection against chemical mutagens

A quantitative model was developed that identified a new function of noncoding sequences in the eukaryotic genome, namely, the protection of coding sequences against chemical (mainly endogenous) mutagens. It was shown that, under common ecological conditions, the number of nucleotides damaged by end...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2006-07, Vol.32 (4), p.368-372
Main Authors: Patrushev, L. I., Minkevich, I. G.
Format: Article
Language:English
Subjects:
Gene sequencing
Genomes
Loci
Mutagens
Nucleotides
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Summary:A quantitative model was developed that identified a new function of noncoding sequences in the eukaryotic genome, namely, the protection of coding sequences against chemical (mainly endogenous) mutagens. It was shown that, under common ecological conditions, the number of nucleotides damaged by endogenous and exogenous reactive species in coding sequences of the genome is inversely proportional to the size of their noncoding parts. Noncoding sequences can differently protect single genetic loci from chemical modification by the formation of specific spatial structures of the protected loci in the interphase nuclei. The significant differences in genome sizes between species (C-value paradox) can be explained by different contributions of noncoding sequences to the total effect of genome protection from endogenous chemical mutagens.
ISSN:1068-1620
1573-9163
1608-330X
DOI:10.1134/S1068162006040078