Effects of solvents and surfactant agents on the female and larvae of cattle tick Boophilus microplus

Many natural compounds have low water solubility and need to be dissolved in organic solvents, or surfactant agents must be used before addition into experimental systems. Therefore, it is necessary to determine their toxicity. Experiments were performed aiming to select solvents to be used in the b...

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Bibliographic Details
Published in:Parasitology research (1987) 2007-05, Vol.100 (6), p.1267-1270
Main Authors: Gonçalves, Karla, Toigo, Eduardo, Ascoli, Bruna, von Poser, Gilsane, Ribeiro, Vera Lucia Sardá
Format: Article
Language:English
Subjects:
Acetone - pharmacology
Animals
Biological and medical sciences
Boophilus microplus
Cattle
Dimethyl Sulfoxide - pharmacology
Ethanol - pharmacology
Female
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Insecticides - pharmacology
Invertebrates
Ixodidae
Ixodidae - drug effects
Larva - drug effects
Medically important nuisances and vectors, pests of stored products and materials: population survey and control
Methanol - pharmacology
Octoxynol - pharmacology
Polysorbates - pharmacology
Solvents - pharmacology
Surface-Active Agents - pharmacology
Vectors. Intermediate hosts
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Summary:Many natural compounds have low water solubility and need to be dissolved in organic solvents, or surfactant agents must be used before addition into experimental systems. Therefore, it is necessary to determine their toxicity. Experiments were performed aiming to select solvents to be used in the bioassays, searching new acaricide agents from plants. Laboratory tests were carried out on larvae and adults of the cattle tick Boophilus microplus to determine the sensibility of B. microplus female and larvae to different solvents (acetone, methanol, ethanol and 1% dimethyl sulfoxide) and surfactant agents (1% Tween 80 and 5% Triton X-100) using the larval immersion test (LIT) and adult immersion test (AIT). In the AIT, the effect of the treatments on engorged females was assessed by measuring egg production and hatching rate. Acetone was toxic to the adults promoting mortality of 100%. Methanol and ethanol caused 45.3 and 14.2% of mortality, respectively. The other tested substances were not toxic to the engorged females of B. microplus. In the LIT, it was observed that the larvae were more resistant; after 48 h, about 100% of the larvae were alive in all the treatments except with acetone that caused a mortality of 10%.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-006-0418-2