Highly Enantioselective One-Pot Synthesis of Chiral Tri- and Tetrasubstituted Ferrocenes from 1,1′-Ferrocenedicarbaldehyde

Exclusively planar chirality is exhibited by the ferrocenes obtained in a highly enantioselective synthesis in which a chiral aminoamide acts as a temporary protecting/directing group. This method was used to obtain an enantiomerically pure tetrasubstituted ferrocene, which was transformed into the...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 1998-07, Vol.37 (12), p.1698-1701
Main Authors: Iftime, Gabriel, Daran, Jean-Claude, Manoury, Eric, Balavoine, Gilbert G. A.
Format: Article
Language:English
Subjects:
Asymmetric synthesis
Chirality
Iron
Metallocenes
Metallocenophanes
Online Access:Get full text
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Summary:Exclusively planar chirality is exhibited by the ferrocenes obtained in a highly enantioselective synthesis in which a chiral aminoamide acts as a temporary protecting/directing group. This method was used to obtain an enantiomerically pure tetrasubstituted ferrocene, which was transformed into the first C2‐symmetric disubstituted ferrocenophane [Eq. (1)].
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(19980703)37:12<1698::AID-ANIE1698>3.0.CO;2-D