A microfluidic glucose sensor incorporating a novel thread‐based electrode system

An electrochemical sensor for the detection of glucose using thread‐based electrodes and fabric is described. This device is relatively simple to fabricate and can be used for multiple readings after washing with ethanol. The fabrication of the chip consisted of two steps. First, three thread‐based...

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Bibliographic Details
Published in:Electrophoresis 2018-08, Vol.39 (16), p.2131-2135
Main Authors: Gaines, Michelle, Gonzalez‐Guerrero, Maria Jose, Uchida, Kathryn, Gomez, Frank A.
Format: Article
Language:English
Subjects:
Beeswax
Carbon
Chemical sensors
Diagnostic device
Electrochemical sensor
Electrochemical Techniques - instrumentation
Electrodes
Equipment Design
Ethanol
Glucose
Glucose - analysis
Glucose oxidase
Glucose Oxidase - metabolism
Microfluidics - methods
Oxidation
Point‐of‐care
Potassium ferricyanide
Sensors
Silver
Silver chloride
Waxes
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Description
Summary:An electrochemical sensor for the detection of glucose using thread‐based electrodes and fabric is described. This device is relatively simple to fabricate and can be used for multiple readings after washing with ethanol. The fabrication of the chip consisted of two steps. First, three thread‐based electrodes (reference, working, and counter) were fabricated by painting pieces of nylon thread with either layered silver ink and carbon ink or silver/silver chloride ink. The threads were then woven into a fabric chip with a beeswax barrier molded around the edges in order to prevent leaks from the tested solutions. A thread‐based working electrode consisting of one layer of silver underneath two layers of carbon was selected to fabricate the final sensor system. Using the chip, a PBS solution containing glucose oxidase (GOx) (10 mg/mL), potassium ferricyanide (K3[Fe(CN)6]) (10 mg/mL) as mediator, and different concentrations of glucose (0‐25 mM), was measured by cyclic voltammetry (CV). It was found that the current output from the oxidation of glucose was proportional to the glucose concentrations. This thread‐based electrode system is a viable sensor platform for detecting glucose in the physiological range.
ISSN:0173-0835
1522-2683
DOI:10.1002/elps.201800010