Loading…
Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study
Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3....
Saved in:
| Published in: | Journal of human hypertension 2018-07, Vol.32 (7), p.487-493 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23 |
| container_end_page | 493 |
| container_issue | 7 |
| container_start_page | 487 |
| container_title | Journal of human hypertension |
| container_volume | 32 |
| creator | Kasiakogias, Alexandros Tsioufis, Costas Dimitriadis, Kyriakos Konstantinidis, Dimitrios Koumelli, Areti Leontsinis, Ioannis Andrikou, Eirini Vogiatzakis, Nikos Marinaki, Smaragdi Petras, Dimitrios Fragoulis, Christos Konstantinou, Konstantinos Papademetriou, Vasilios Tousoulis, Dimitrios |
| description | Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP |
| doi_str_mv | 10.1038/s41371-018-0065-y |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2033382745</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A572719542</galeid><sourcerecordid>A572719542</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23</originalsourceid><addsrcrecordid>eNp1kl2L1DAUhoMo7rj6A7yRgCDeZM1n03q3DH7Bgjd6HdL0ZKZL24xJOkvBH2_KrLuuKLkIyXnOm5yXF6GXjF4wKup3STKhGaGsJpRWiiyP0IZJXRGluH6MNrRRlDRc0jP0LKVrStdi_RSd8UYzQaXeoJ9bG7s-HG1y82AjHkNs-67PCw4eJzhCBBwh9SnbKeP9coCYYUp9mLAdw7TDOYLN0OF5cmHKMQxDOdxzR0jvscWSLFDUfSmHGzIfcMpztzxHT7wdEry43c_R948fvm0_k6uvn75sL6-Ik5pmoiora1p574ArLpmsrXeqq6XTXdvUlVCu9RUVXDFmGXVt2Zy2wkrpedNycY7ennQPMfyYIWUz9snBMNgJwpwMp0KImmupCvr6L_Q6zHEqvyuULr6qplh_R-3sAKaffMjRulXUXCrNNWuUXJ-9-AdVVgdjX9wC35f7Bw1v_mjYgx3yPoVhzsXu9BBkJ9DFkFIEbw6xH21cDKNmjYY5RcOUaJg1GmYpPa9uJ5vbEbq7jt9ZKAA_AamUph3E-9H_r_oLZq7ETQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2075525910</pqid></control><display><type>article</type><title>Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study</title><source>Springer Nature</source><source>Alma/SFX Local Collection</source><creator>Kasiakogias, Alexandros ; Tsioufis, Costas ; Dimitriadis, Kyriakos ; Konstantinidis, Dimitrios ; Koumelli, Areti ; Leontsinis, Ioannis ; Andrikou, Eirini ; Vogiatzakis, Nikos ; Marinaki, Smaragdi ; Petras, Dimitrios ; Fragoulis, Christos ; Konstantinou, Konstantinos ; Papademetriou, Vasilios ; Tousoulis, Dimitrios</creator><creatorcontrib>Kasiakogias, Alexandros ; Tsioufis, Costas ; Dimitriadis, Kyriakos ; Konstantinidis, Dimitrios ; Koumelli, Areti ; Leontsinis, Ioannis ; Andrikou, Eirini ; Vogiatzakis, Nikos ; Marinaki, Smaragdi ; Petras, Dimitrios ; Fragoulis, Christos ; Konstantinou, Konstantinos ; Papademetriou, Vasilios ; Tousoulis, Dimitrios</creatorcontrib><description>Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP < 160 mmHg) and 200 (12%) with severe RHTN (systolic BP ≥ 160 mmHg). Endpoint of interest was cardiovascular morbidity set as the composite of coronary heart disease and stroke. During follow-up, incidence rates of cardiovascular events per 1000 person-years were 7.1 cases in the non-RHTN group, 12.4 cases in the not-severe RHTN group and 18 cases in the severe RHTN group. Unadjusted analysis showed that compared to uncontrolled patients without RHTN, patients with not-severe RHTN exhibited a similar risk but patients with severe RHTN had a significantly higher risk, by 2.5 times (CI: 1.28–4.73,
p
= 0.007). Even after multivariate adjustment for established risk factors including BP levels and isolated systolic HTN, severe RHTN remained as an independent predictor of the cardiovascular outcome (OR: 2.30, CI: 1.00–5.29,
p
= 0.05). In conclusion, among treated yet uncontrolled hypertensive patients, severe RHTN exhibits a significantly higher cardiovascular risk indicating the need for prompt management.</description><identifier>ISSN: 0950-9240</identifier><identifier>EISSN: 1476-5527</identifier><identifier>DOI: 10.1038/s41371-018-0065-y</identifier><identifier>PMID: 29713047</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/75/243 ; 692/700/1750 ; Blood pressure ; Cardiovascular disease ; Cardiovascular diseases ; Care and treatment ; Coronary artery disease ; Development and progression ; Diagnosis ; Epidemiology ; Health Administration ; Health risk assessment ; Heart diseases ; Hypertension ; Medicine ; Medicine & Public Health ; Morbidity ; Prognosis ; Public Health ; Risk factors</subject><ispartof>Journal of human hypertension, 2018-07, Vol.32 (7), p.487-493</ispartof><rights>Macmillan Publishers Limited, part of Springer Nature 2018</rights><rights>COPYRIGHT 2018 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jul 2018</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23</citedby><cites>FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23</cites><orcidid>0000-0002-7636-6725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29713047$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kasiakogias, Alexandros</creatorcontrib><creatorcontrib>Tsioufis, Costas</creatorcontrib><creatorcontrib>Dimitriadis, Kyriakos</creatorcontrib><creatorcontrib>Konstantinidis, Dimitrios</creatorcontrib><creatorcontrib>Koumelli, Areti</creatorcontrib><creatorcontrib>Leontsinis, Ioannis</creatorcontrib><creatorcontrib>Andrikou, Eirini</creatorcontrib><creatorcontrib>Vogiatzakis, Nikos</creatorcontrib><creatorcontrib>Marinaki, Smaragdi</creatorcontrib><creatorcontrib>Petras, Dimitrios</creatorcontrib><creatorcontrib>Fragoulis, Christos</creatorcontrib><creatorcontrib>Konstantinou, Konstantinos</creatorcontrib><creatorcontrib>Papademetriou, Vasilios</creatorcontrib><creatorcontrib>Tousoulis, Dimitrios</creatorcontrib><title>Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study</title><title>Journal of human hypertension</title><addtitle>J Hum Hypertens</addtitle><addtitle>J Hum Hypertens</addtitle><description>Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP < 160 mmHg) and 200 (12%) with severe RHTN (systolic BP ≥ 160 mmHg). Endpoint of interest was cardiovascular morbidity set as the composite of coronary heart disease and stroke. During follow-up, incidence rates of cardiovascular events per 1000 person-years were 7.1 cases in the non-RHTN group, 12.4 cases in the not-severe RHTN group and 18 cases in the severe RHTN group. Unadjusted analysis showed that compared to uncontrolled patients without RHTN, patients with not-severe RHTN exhibited a similar risk but patients with severe RHTN had a significantly higher risk, by 2.5 times (CI: 1.28–4.73,
p
= 0.007). Even after multivariate adjustment for established risk factors including BP levels and isolated systolic HTN, severe RHTN remained as an independent predictor of the cardiovascular outcome (OR: 2.30, CI: 1.00–5.29,
p
= 0.05). In conclusion, among treated yet uncontrolled hypertensive patients, severe RHTN exhibits a significantly higher cardiovascular risk indicating the need for prompt management.</description><subject>692/699/75/243</subject><subject>692/700/1750</subject><subject>Blood pressure</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Care and treatment</subject><subject>Coronary artery disease</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Epidemiology</subject><subject>Health Administration</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Hypertension</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Morbidity</subject><subject>Prognosis</subject><subject>Public Health</subject><subject>Risk factors</subject><issn>0950-9240</issn><issn>1476-5527</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kl2L1DAUhoMo7rj6A7yRgCDeZM1n03q3DH7Bgjd6HdL0ZKZL24xJOkvBH2_KrLuuKLkIyXnOm5yXF6GXjF4wKup3STKhGaGsJpRWiiyP0IZJXRGluH6MNrRRlDRc0jP0LKVrStdi_RSd8UYzQaXeoJ9bG7s-HG1y82AjHkNs-67PCw4eJzhCBBwh9SnbKeP9coCYYUp9mLAdw7TDOYLN0OF5cmHKMQxDOdxzR0jvscWSLFDUfSmHGzIfcMpztzxHT7wdEry43c_R948fvm0_k6uvn75sL6-Ik5pmoiora1p574ArLpmsrXeqq6XTXdvUlVCu9RUVXDFmGXVt2Zy2wkrpedNycY7ennQPMfyYIWUz9snBMNgJwpwMp0KImmupCvr6L_Q6zHEqvyuULr6qplh_R-3sAKaffMjRulXUXCrNNWuUXJ-9-AdVVgdjX9wC35f7Bw1v_mjYgx3yPoVhzsXu9BBkJ9DFkFIEbw6xH21cDKNmjYY5RcOUaJg1GmYpPa9uJ5vbEbq7jt9ZKAA_AamUph3E-9H_r_oLZq7ETQ</recordid><startdate>20180701</startdate><enddate>20180701</enddate><creator>Kasiakogias, Alexandros</creator><creator>Tsioufis, Costas</creator><creator>Dimitriadis, Kyriakos</creator><creator>Konstantinidis, Dimitrios</creator><creator>Koumelli, Areti</creator><creator>Leontsinis, Ioannis</creator><creator>Andrikou, Eirini</creator><creator>Vogiatzakis, Nikos</creator><creator>Marinaki, Smaragdi</creator><creator>Petras, Dimitrios</creator><creator>Fragoulis, Christos</creator><creator>Konstantinou, Konstantinos</creator><creator>Papademetriou, Vasilios</creator><creator>Tousoulis, Dimitrios</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7636-6725</orcidid></search><sort><creationdate>20180701</creationdate><title>Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study</title><author>Kasiakogias, Alexandros ; Tsioufis, Costas ; Dimitriadis, Kyriakos ; Konstantinidis, Dimitrios ; Koumelli, Areti ; Leontsinis, Ioannis ; Andrikou, Eirini ; Vogiatzakis, Nikos ; Marinaki, Smaragdi ; Petras, Dimitrios ; Fragoulis, Christos ; Konstantinou, Konstantinos ; Papademetriou, Vasilios ; Tousoulis, Dimitrios</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/699/75/243</topic><topic>692/700/1750</topic><topic>Blood pressure</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Care and treatment</topic><topic>Coronary artery disease</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Epidemiology</topic><topic>Health Administration</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Hypertension</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Morbidity</topic><topic>Prognosis</topic><topic>Public Health</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kasiakogias, Alexandros</creatorcontrib><creatorcontrib>Tsioufis, Costas</creatorcontrib><creatorcontrib>Dimitriadis, Kyriakos</creatorcontrib><creatorcontrib>Konstantinidis, Dimitrios</creatorcontrib><creatorcontrib>Koumelli, Areti</creatorcontrib><creatorcontrib>Leontsinis, Ioannis</creatorcontrib><creatorcontrib>Andrikou, Eirini</creatorcontrib><creatorcontrib>Vogiatzakis, Nikos</creatorcontrib><creatorcontrib>Marinaki, Smaragdi</creatorcontrib><creatorcontrib>Petras, Dimitrios</creatorcontrib><creatorcontrib>Fragoulis, Christos</creatorcontrib><creatorcontrib>Konstantinou, Konstantinos</creatorcontrib><creatorcontrib>Papademetriou, Vasilios</creatorcontrib><creatorcontrib>Tousoulis, Dimitrios</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of human hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kasiakogias, Alexandros</au><au>Tsioufis, Costas</au><au>Dimitriadis, Kyriakos</au><au>Konstantinidis, Dimitrios</au><au>Koumelli, Areti</au><au>Leontsinis, Ioannis</au><au>Andrikou, Eirini</au><au>Vogiatzakis, Nikos</au><au>Marinaki, Smaragdi</au><au>Petras, Dimitrios</au><au>Fragoulis, Christos</au><au>Konstantinou, Konstantinos</au><au>Papademetriou, Vasilios</au><au>Tousoulis, Dimitrios</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study</atitle><jtitle>Journal of human hypertension</jtitle><stitle>J Hum Hypertens</stitle><addtitle>J Hum Hypertens</addtitle><date>2018-07-01</date><risdate>2018</risdate><volume>32</volume><issue>7</issue><spage>487</spage><epage>493</epage><pages>487-493</pages><issn>0950-9240</issn><eissn>1476-5527</eissn><abstract>Data regarding the prognosis of resistant hypertension (RHTN) with respect to its severity is limited. We investigated the cardiovascular risk of severe RHTN in a prospective observational study. A cohort of 1700 hypertensive patient with treated uncontrolled HTN was followed for a mean period of 3.6 ± 1.8 years. At baseline, standard clinical and laboratory workup was performed, including testing for secondary causes of RHT where applicable. Three groups were identified depending on presence of RHTN (office-based uncontrolled HTN under at least three drugs including a diuretic) and levels of office systolic blood pressure (BP): 1187 patients (70%) without RHTN, 313 (18%) with not-severe RHTN (systolic BP < 160 mmHg) and 200 (12%) with severe RHTN (systolic BP ≥ 160 mmHg). Endpoint of interest was cardiovascular morbidity set as the composite of coronary heart disease and stroke. During follow-up, incidence rates of cardiovascular events per 1000 person-years were 7.1 cases in the non-RHTN group, 12.4 cases in the not-severe RHTN group and 18 cases in the severe RHTN group. Unadjusted analysis showed that compared to uncontrolled patients without RHTN, patients with not-severe RHTN exhibited a similar risk but patients with severe RHTN had a significantly higher risk, by 2.5 times (CI: 1.28–4.73,
p
= 0.007). Even after multivariate adjustment for established risk factors including BP levels and isolated systolic HTN, severe RHTN remained as an independent predictor of the cardiovascular outcome (OR: 2.30, CI: 1.00–5.29,
p
= 0.05). In conclusion, among treated yet uncontrolled hypertensive patients, severe RHTN exhibits a significantly higher cardiovascular risk indicating the need for prompt management.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29713047</pmid><doi>10.1038/s41371-018-0065-y</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7636-6725</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9240 |
| ispartof | Journal of human hypertension, 2018-07, Vol.32 (7), p.487-493 |
| issn | 0950-9240 1476-5527 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2033382745 |
| source | Springer Nature; Alma/SFX Local Collection |
| subjects | 692/699/75/243 692/700/1750 Blood pressure Cardiovascular disease Cardiovascular diseases Care and treatment Coronary artery disease Development and progression Diagnosis Epidemiology Health Administration Health risk assessment Heart diseases Hypertension Medicine Medicine & Public Health Morbidity Prognosis Public Health Risk factors |
| title | Cardiovascular morbidity of severe resistant hypertension among treated uncontrolled hypertensives: a 4-year follow-up study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-28T11%3A39%3A42IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cardiovascular%20morbidity%20of%20severe%20resistant%20hypertension%20among%20treated%20uncontrolled%20hypertensives:%20a%204-year%20follow-up%20study&rft.jtitle=Journal%20of%20human%20hypertension&rft.au=Kasiakogias,%20Alexandros&rft.date=2018-07-01&rft.volume=32&rft.issue=7&rft.spage=487&rft.epage=493&rft.pages=487-493&rft.issn=0950-9240&rft.eissn=1476-5527&rft_id=info:doi/10.1038/s41371-018-0065-y&rft_dat=%3Cgale_proqu%3EA572719542%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c470t-56a4806ffce2524148afc5d84c7db98635cbf6032511a10cb11ac7a3a44f29b23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2075525910&rft_id=info:pmid/29713047&rft_galeid=A572719542&rfr_iscdi=true |