Counterpoint: Vancomycin and Staphylococcus aureus—An Antibiotic Enters Obsolescence

The efficacy of vancomycin for the treatment of patients with infections due to Staphylococcus aureus is impaired by its poor tissue penetration and by its relatively weak antibacterial activity-an activity that is declining as S. aureus evolves. Neither dose escalation nor use of vancomycin in comb...

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Bibliographic Details
Published in:Clinical infectious diseases 2007-06, Vol.44 (12), p.1543-1548
Main Author: Deresinski, Stan
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - pharmacology
Antibiotics
Antimicrobials
Bacteremia
Bacteria
Clinical outcomes
Dosage
Drug dosages
Drug Resistance, Bacterial
Drug therapy
Endocarditis
Evolution, Molecular
Humans
IDSA Lecture
Infections
Infectious diseases
Medical treatment
Methicillin Resistance - drug effects
Microbial Sensitivity Tests - methods
Microbiology
Randomized Controlled Trials as Topic
Staphylococcal Infections - drug therapy
Staphylococcus aureus
Staphylococcus aureus - drug effects
Treatment Outcome
Vancomycin - administration & dosage
Vancomycin - pharmacokinetics
Vancomycin - pharmacology
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