Inflammatory Responses and Oxidative Stress From Metal Fume Exposure in Automobile Welders

Objectives: Welding operations expose to metal fume. We investigated the inflammatory responses and oxidative stress from metal fume exposure in an automobile plant Methods: We recruited 258 automobile workers and measured the urine zinc, copper, and nickel to determine the exposure level, and exami...

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Bibliographic Details
Published in:Journal of occupational and environmental medicine 2009-01, Vol.51 (1), p.95-103
Main Authors: Luo, Jiin-Chyuan John, Hsu, Kuang-Hung, Shen, Wu-Shiun
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Air Pollutants, Occupational - blood
Air Pollutants, Occupational - urine
Automobile industry
Automobiles
Biological and medical sciences
Biomarkers - blood
Biomarkers - urine
Chemical and industrial products toxicology. Toxic occupational diseases
Cytokines
Fever - chemically induced
Glutathione - blood
Heavy metals
Human exposure
Humans
Inflammatory diseases
Inhalation Exposure - adverse effects
Interleukin-6 - blood
Leukocytes
Male
Medical sciences
Metal workers
Metals and various inorganic compounds
Metals, Heavy - urine
Middle Aged
Occupational Exposure - adverse effects
Occupational health
ORIGINAL ARTICLES
Oxidative Stress
Regression Analysis
Smoking - epidemiology
Toxicology
Welding
Young Adult
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Summary:Objectives: Welding operations expose to metal fume. We investigated the inflammatory responses and oxidative stress from metal fume exposure in an automobile plant Methods: We recruited 258 automobile workers and measured the urine zinc, copper, and nickel to determine the exposure level, and examined the white blood cells, and IL-6 as inflammatory responses to the metal fume exposure. We also examined the relationship between glutathione (GSH) and metals exposure. Results: There were significant association between urine metals levels and welding hours. Zinc was significantly associated with blood white cells, interleukin-6, and GSH. Copper was significantly associated with GSH, but nickel was significantly inversely associate with GSH. Conclusions: Automobile welders appear to have significan metals exposure. White blood cells and IL-6 might be involved in inflammatory process of zinc fume exposure with zinc and copper increasing GSH, but nickel deputing it.
ISSN:1076-2752
1536-5948
DOI:10.1097/JOM.0b013e31818f756e