Mesenchymal Stem Cell Sheets Exert Antistenotic Effects in a Rat Arterial Injury Model

Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease. Mesenchymal stem cells (MSCs) may have antistenotic effects on injured arteries. MSC transplantation from the adventitial side of an artery is safer than endovascular transplantation...

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Bibliographic Details
Published in:Tissue engineering. Part A 2018-10, Vol.24 (19-20), p.1545-1553
Main Authors: Homma, Jun, Sekine, Hidekazu, Matsuura, Katsuhisa, Kobayashi, Eiji, Shimizu, Tatsuya
Format: Article
Language:English
Subjects:
Actin
Animals
Bioluminescence
Biomedical engineering
Cardiovascular system
Catheters
Cell proliferation
Cell suspensions
Disease
Endothelial cells
Femoral artery
Femur
Heart attacks
Histone H3
Hyperplasia
Immunohistochemistry
Lymphocytes
Mesenchymal stem cells
Mesenchyme
Original Articles
Restenosis
Rodents
Smooth muscle
Stem cell transplantation
Stem cells
Studies
Womens health
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Summary:Restenosis after catheter or surgical intervention substantially affects the prognosis of arterial occlusive disease. Mesenchymal stem cells (MSCs) may have antistenotic effects on injured arteries. MSC transplantation from the adventitial side of an artery is safer than endovascular transplantation but has not been extensively examined. In this study, a rat model of femoral artery injury was used to compare the antistenotic effects of transplanted cell sheets and transplanted cell suspensions. Rat adipose-derived stem cells (ASCs) were used as the source of MSCs. For both cell sheets and suspensions, 6 × 10 6 MSCs were transplanted on the day of arterial injury. MSC sheets attenuated neointimal hyperplasia more than MSC suspensions (intima-to-media ratio in hematoxylin/eosin-stained sections: 0.55 ± 0.13 vs. 1.14 ± 0.12; p  
ISSN:1937-3341
1937-335X
DOI:10.1089/ten.tea.2018.0030