Multimodal brain imaging investigation of self-reported sleep quality and daytime sleepiness in older adults with heart failure

Purpose of the study: Individuals with heart failure (HF) have a high frequency of sleep problems. Patients with HF present with structural brain changes different from normal aging including reductions in brain volume, increases in white matter hyperintensity (WMH) and reduced cerebral blood flow....

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Bibliographic Details
Published in:International journal of neuroscience 2018-11, Vol.128 (11), p.1044-1051
Main Authors: Moon, Chooza, Melah, Kelsey E., Rivera-Rivera, Leonardo A., Bratzke, Lisa C.
Format: Article
Language:English
Subjects:
Aged
brain
Brain - blood supply
Brain - diagnostic imaging
Brain - pathology
Brain - physiopathology
excessive daytime sleepiness
Female
Heart failure
Heart Failure - complications
Heart Failure - pathology
Heart Failure - physiopathology
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Multimodal Imaging
neuroradiology
Self Report
Sleep
sleep quality
Sleepiness
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Summary:Purpose of the study: Individuals with heart failure (HF) have a high frequency of sleep problems. Patients with HF present with structural brain changes different from normal aging including reductions in brain volume, increases in white matter hyperintensity (WMH) and reduced cerebral blood flow. These structural changes in the brain may explain the pathophysiology of sleep and daytime problems. The objective of this study was to determine whether multimodal imaging data are related to self-reported sleep problems and daytime sleepiness in older adults with HF. Methods: Participants in this study underwent magnetic resonance imaging scans on the General Electric 3.0 T Discovery MR750 to acquire WMH, cerebral blood flow and brain volume. Data on 37 stable HF patients (mean age = 68; SD = 5.75) were included. Results: In this sample, WMH was associated with daytime sleepiness (p = 0.025). However, gray and white matter volume and cerebral blood flow were not associated with daytime sleepiness, sleep quality or insomnia. Conclusion: Although further studies are needed to determine the relationship between WMH and sleep and daytime problems, the findings preliminarily support that increases in WMH from ischemic changes could explain increases in daytime sleepiness among people with HF.
ISSN:0020-7454
1563-5279
1543-5245
1563-5279
DOI:10.1080/00207454.2018.1475374