The potential role of a turbidimetric heart-type fatty acid-binding protein assay to aid in the interpretation of persistently elevated, non-changing, cardiac troponin I concentrations

Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H...

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Bibliographic Details
Published in:Clinical biochemistry 2018-08, Vol.58, p.53-59
Main Authors: Kavsak, Peter A., Ainsworth, Craig, Arnold, Donald M., Scott, Terry, Clark, Lorna, Ivica, Josko, Mackett, Katharine, Whitlock, Richard, Worster, Andrew
Format: Article
Language:English
Subjects:
H-FABP
High-sensitivity cardiac troponin
Macrocomplexes
Myocardial injury
Stability
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Summary:Elevated and non-changing high-sensitivity cardiac troponin (hs-cTn) concentrations may suggest a process other than acute injury, possibly due to chronic condition(s) causing the elevation, an analytical error/interference or the formation of macrocomplexes. Heart-type fatty acid binding protein (H-FABP) might be useful in this setting to identify the etiology of abnormally high and non-changing cTn concentrations which could aid clinical decision making in the hospital setting. We analytically validated the H-FABP assay (Randox) on the Abbott ARICHTECTc8000 platform, testing imprecision, linearity, stability, and matrix comparison. Over the 2-month analytical validation; EDTA plasma samples from patients with a hospital visit with persistently elevated and stable cTnI concentrations (Abbott hs-cTnI≥52 ng/L or 2x99th percentile upper limit of normal (ULN = 26 ng/L) with change between results
ISSN:0009-9120
1873-2933
DOI:10.1016/j.clinbiochem.2018.05.006