Neuromelanin imaging and midbrain volumetry in progressive supranuclear palsy and Parkinson's disease

ABSTRACT Background Nigral degeneration patterns differ between PSP and PD. However, the relationship between nigral degeneration and midbrain atrophy in PSP remains unclear. Objective We analyzed differences and relationships between nigral degeneration and midbrain atrophy in PSP and PD. Methods N...

Full description

Saved in:
Bibliographic Details
Published in:Movement disorders 2018-09, Vol.33 (9), p.1488-1492
Main Authors: Taniguchi, Daisuke, Hatano, Taku, Kamagata, Koji, Okuzumi, Ayami, Oji, Yutaka, Mori, Akio, Hori, Masaaki, Aoki, Shigeki, Hattori, Nobutaka
Format: Article
Language:English
Subjects:
Atrophy
Degeneration
Magnetic resonance imaging
Mesencephalon
midbrain
Movement disorders
Neurodegenerative diseases
neuromelanin
Paralysis
Parkinson's disease
Progressive supranuclear palsy
Substantia nigra
volumetry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background Nigral degeneration patterns differ between PSP and PD. However, the relationship between nigral degeneration and midbrain atrophy in PSP remains unclear. Objective We analyzed differences and relationships between nigral degeneration and midbrain atrophy in PSP and PD. Methods Neuromelanin‐sensitive MRI and midbrain volumetry were performed in 11 PSP patients, 24 PD patients, and 10 controls to measure the neuromelanin‐sensitive SNpc area and midbrain volume. Results The neuromelanin‐sensitive SNpc area and midbrain volume were significantly smaller in PSP patients compared with PD patients and controls. Motor deficits were inversely correlated with neuromelanin‐sensitive SNpc area in PD, but not PSP patients. There was no significant correlation between neuromelanin‐sensitive SNpc area and midbrain volume in either disease group. Midbrain volumetry discriminated PSP from PD. Diagnostic accuracy was improved when neuromelanin‐sensitive MRI analysis was added. Conclusions Neuromelanin‐sensitive MRI and midbrain volumetry may reflect the clinical and pathological characteristics of PSP and PD. Combining neuromelanin‐sensitive MRI and midbrain volumetry may be useful for differentiating PSP from PD. © 2018 International Parkinson and Movement Disorder Society
ISSN:0885-3185
1531-8257
DOI:10.1002/mds.27365