Obesity‐Associated Diseases Biomarkers Are Differently Modulated in Lean and Obese Individuals and Inversely Correlated to Plasma Polyphenolic Metabolites After 6 Weeks of Mango (Mangifera indica L.) Consumption

• Published in: Molecular nutrition & food research 2018-07, Vol.62 (14), p.e1800129-n/a
• Main Authors: Fang, Chuo, Kim, Hyemee, Barnes, Ryan C., Talcott, Stephen T., Mertens‐Talcott, Susanne U.
• Format: Article
• Language: English
• Subjects: Biomarkers; Blood pressure; Body mass; Body mass index; Body size; Chronic illnesses; clinical study; Correlation analysis; Cytokines; Diseases; Gallotannin; gallotannin derivatives; Health risks; Hemoglobin; Hormones; Inflammation; Interleukins; Mangoes; metabolic functions; Metabolism; Metabolites; Monocyte chemoattractant protein; Monocytes; Obesity; Plasma levels; Plasminogen activator inhibitors; Polyphenols; Proteins; Pulp; Risk analysis; Risk factors; Supplements
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.201800129

Scope Mangos are a rich source of gallotannin‐derived polyphenols that may exert anti‐inflammatory effects relevant to obesity‐related chronic diseases. This randomized human clinical study investigated the influence of daily mango supplementation for 6 weeks on inflammation and metabolic functions in lean and obese individuals. Methods and results Lean (n = 12, body mass index [BMI] 18–26.2 kg m−2) and obese (n = 9, BMI >28.9 kg m−2) participants, aged 18–65 years received daily 400 g of mango pulp for 6 weeks. Inflammatory cytokines, metabolic hormones, and lipid profiles were examined in plasma before and after 6 weeks. In lean participants, systolic blood pressure was lowered by 4 mmHg after 6 weeks. In obese participants, hemoglobin A1c (HbA1c) and plasminogen activator inhibitor‐1 (PAI‐1) were reduced by 18% and 20%, respectively. Obese participants showed decreased plasma concentrations (area under the curve [AUC] 0–8h) of interleukin‐8 (IL‐8) and monocyte chemoattractant protein‐1 (MCP‐1). Correlation analysis indicates that the beneficial effects of mango supplementation on pro‐inflammatory cytokines, PAI‐1 and HbA1c, are associated with systemic exposure to polyphenolic metabolites. Conclusions Mango supplementation improves the plasma levels of pro‐inflammatory cytokines and metabolic hormones in obese participants. There is a crucial need to investigate the role of lowered polyphenolic absorption in obese individuals on their efficacy in reducing biomarkers for inflammation and other risk factors for chronic diseases. Mango supplementation improves the plasma levels of pro‐inflammatory cytokines (interleukin‐8 [IL‐8] and monocyte chemoattractant protein‐1 [MCP‐1]) and metabolic hormones hemoglobin A1c (HbA1c) and plasminogen activator inhibitor‐1 (PAI‐1) in obese participants, but not lean participants. Correlation analysis indicates that the beneficial effects of continuous mango supplementation on pro‐inflammatory cytokines, PAI‐1 and HbA1c, are associated with systemic exposure to gallotannin metabolites.