Methamphetamine induces increased levels of interferon-stimulated protein in human primary astrocytes

Methamphetamine (MA) has been shown to be toxic to varying neuronal populations in the striatum, hippocampus and frontal cortex and this effect was greater with the presence of HIV encephalitis (HIVE). Exposure of mesencephalic, striatal and cortical astrocytes to MA has been shown to increase the p...

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Bibliographic Details
Published in:Journal of neurovirology 2007-01, Vol.13, p.86-86
Main Authors: Hult, B J, Paulino, A, Chana, G, Adame, A, Masliah, E, Everall, I P
Format: Article
Language:English
Online Access:Get full text
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Summary:Methamphetamine (MA) has been shown to be toxic to varying neuronal populations in the striatum, hippocampus and frontal cortex and this effect was greater with the presence of HIV encephalitis (HIVE). Exposure of mesencephalic, striatal and cortical astrocytes to MA has been shown to increase the presence of reactive oxygen species, suggesting a mechanism for astroglia-dependent MA neurotoxicity. We have reported that interferon stimulated gene, 15kD (ISG15) expression is increased in post-mortem tissue from the frontal cortex of patients with HIVE and HIVE+ MA use, versus HIV alone, using microarray analysis, qRT-PCR, and immunohistochemistry. As astrocytic cells are immunocompetent and are capable of releasing proinflammatory chemokines and cytokines, the upregulation of ISG15 may play a role in the neurotoxicity of MA and HIV. Confirmation of this effect in an in vitro system would allow for further investigation of the cause and effect of ISG15 upregulation.
ISSN:1355-0284