Impact of glycemic variability on myocardial infarct size in patients with ST-segment elevation myocardial infarction: quantitative assessment of left ventricular wall motion severity

Glycemic variability (GV) is relevant to impaired myocardial salvage in acute ST-elevation myocardial infarction (STEMI). Severity of hypokinesis at the infarct site as assessed from contrast left ventriculography can reportedly predict infarct size in STEMI. We prospectively studied 58 consecutive...

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Published in:Cardiovascular intervention and therapeutics 2019-04, Vol.34 (2), p.122-130
Main Authors: Tsuchida, Keiichi, Nishida, Kota, Soda, Satoshi, Akiyama, Takumi, Hakamata, Takahiro, Sudo, Koji, Tanaka, Komei, Hosaka, Yukio, Takahashi, Kazuyoshi, Oda, Hirotaka
Format: Article
Language:English
Subjects:
Cardiology
Interventional Radiology
Medicine
Medicine & Public Health
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Summary:Glycemic variability (GV) is relevant to impaired myocardial salvage in acute ST-elevation myocardial infarction (STEMI). Severity of hypokinesis at the infarct site as assessed from contrast left ventriculography can reportedly predict infarct size in STEMI. We prospectively studied 58 consecutive patients (mean age, 63 ± 11 years) with anterior or inferior STEMI who underwent successful reperfusion therapy. Mean amplitude of glucose excursion (MAGE) was obtained from continuous glucose monitoring system. Patients were divided into the upper tertile of MAGE as Group H, and the other two-thirds as Group L. Serial regional wall motion severity at the infarct site was computed postprocedure and at follow-up using a quantitative left ventricular analysis system. Impaired myocardial salvage was defined as severity recovery ratio 
ISSN:1868-4300
1868-4297
DOI:10.1007/s12928-018-0531-z