Vitamin D status in adult patients with nonmelanoma skin cancer in Cape Town, South Africa: a cross‐sectional study

Background Ultraviolet (UV) radiation is the most important environmental risk factor for the development of nonmelanoma skin cancer (NMSC). UV radiation is, however, also vital in the formation of vitamin D in humans. Strict sun protection advised to skin cancer patients may lead to vitamin D defic...

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Bibliographic Details
Published in:International journal of dermatology 2018-08, Vol.57 (8), p.922-927
Main Authors: Deventer, Linda, Kannenberg, Susanna M.H., Toit, Jacques
Format: Article
Language:English
Subjects:
25-Hydroxyvitamin D
Aged
Background radiation
Basal cell carcinoma
Cancer
Carcinoma, Basal Cell - blood
Carcinoma, Squamous Cell - blood
Cross-Sectional Studies
Ecological risk assessment
Environmental risk
Epidemiology
Female
Females
Humans
Male
Males
Middle Aged
Patients
Risk analysis
Risk factors
Seasons
Sex Factors
Skin cancer
Skin Neoplasms - blood
Skin Pigmentation
South Africa - epidemiology
Squamous cell carcinoma
Summer
Sunscreening Agents - therapeutic use
Ultraviolet radiation
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - epidemiology
Vitamin deficiency
Winter
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Summary:Background Ultraviolet (UV) radiation is the most important environmental risk factor for the development of nonmelanoma skin cancer (NMSC). UV radiation is, however, also vital in the formation of vitamin D in humans. Strict sun protection advised to skin cancer patients may lead to vitamin D deficiency, yet vitamin D may have a protective effect against cancer formation. Objectives The primary aim was to determine whether patients with nonmelanoma skin cancer at our institution were vitamin D deficient. Methods 25‐Hydroxyvitamin D (25[OH]D) levels were determined in 109 patients with a diagnosis of basal cell carcinoma (BCC) and/or squamous cell carcinoma (SCC) during the summer and winter of 2015 at the Tygerberg Academic Hospital in Cape Town, South Africa. Associations between clinical and epidemiological data and the 25(OH)D level results were investigated. Vitamin D deficiency was defined as total 25(OH)D levels
ISSN:0011-9059
1365-4632
DOI:10.1111/ijd.14068