Copper‐Catalyzed Borocarbonylative Coupling of Internal Alkynes with Unactivated Alkyl Halides: Modular Synthesis of Tetrasubstituted β‐Borylenones

Reported is a general procedure to synthesize tetrasubstituted enones, which are borylated in the β‐position, using a copper‐catalyzed four‐component coupling reaction of simple chemical feedstocks: internal alkynes, alkyl halides, bis(pinacolato)diboron (B2pin2), and CO. A broad scope of highly fun...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2018-08, Vol.57 (32), p.10328-10332
Main Authors: Cheng, Li‐Jie, Mankad, Neal P.
Format: Article
Language:English
Subjects:
Alcohols
Alkynes
boron
Copper
Coupling
Halides
Halogenation
multicomponent reactions
Organic chemistry
Organic compounds
Oxidation
Purification
Synthesis
synthetic methods
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