miR-144-5p Enhances the Radiosensitivity of Non-Small-Cell Lung Cancer Cells via Targeting ATF2

MicroRNAs (miRNAs or miRs) regulate gene expression at the posttranscriptional level and are involved in many biological processes such as cell proliferation and migration, stem cell differentiation, inflammation, and apoptosis. In particular, miR-144-3p is downregulated in various cancers, and its...

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Bibliographic Details
Published in:	BioMed research international 2018-01, Vol.2018 (2018), p.1-10
Main Authors:	Li, Dan, Wang, Ying, Jie, Jing, Ma, Lianjun, Li, Xiaoping, Hua, Shucheng, Chen, Wei, Song, Lei, Chen, Dong
Format:	Article
Language:	English
Subjects:	Activating transcription factor 2 Activating Transcription Factor 2 - genetics Activating Transcription Factor 2 - metabolism Animals Apoptosis Apoptosis - genetics Apoptosis - radiation effects Base Sequence Bioinformatics Biological activity Cancer Cancer cells Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Cell culture Cell differentiation Cell growth Cell Line, Tumor Cell migration Cell proliferation Cell Survival - genetics Cell Survival - radiation effects Deregulation Differentiation (biology) Gene expression Gene Expression Regulation, Neoplastic - radiation effects Health aspects Humans Lung cancer Lung cancer, Non-small cell Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical prognosis Metastases Mice, Inbred BALB C Mice, Nude MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Non-small cell lung carcinoma Oncology Post-transcription Radiation Radiation therapy Radiation Tolerance - genetics Radiation Tolerance - radiation effects Radiation, Ionizing Radiosensitivity Restoration Stem cells Therapeutic applications Transcription factors Xenografts Xenotransplantation
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