Sodium and asthma: something borrowed, something new?

1 Smooth Muscle Research Group, University of Calgary, Calgary, Alberta; and 2 The Firestone Institute for Respiratory Health, Saint Joseph's Hospital, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada ABSTRACT Some early studies have called attention to the potential c...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2007-12, Vol.293 (6), p.L1369-L1373
Main Authors: Hirota, Simon A, Janssen, Luke J
Format: Article
Language:English
Subjects:
Airway management
Animals
Asthma
Asthma - metabolism
Homeostasis
Humans
Hypertension
Hypertension - physiopathology
Muscle Contraction
Muscle, Smooth - enzymology
Muscular system
Rats
Sodium
Sodium - metabolism
Sodium Chloride, Dietary - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
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Summary:1 Smooth Muscle Research Group, University of Calgary, Calgary, Alberta; and 2 The Firestone Institute for Respiratory Health, Saint Joseph's Hospital, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada ABSTRACT Some early studies have called attention to the potential contribution of sodium (both dietary and serum levels) in airway-related disease, although the picture was not entirely clear. Two recent developments may now allow a more careful consideration of this: first, the greatly improved understanding of the role of salt in hypertension (particularly the identification of subgroups of salt-sensitive individuals within the general population), and second, the recent discovery of the role of the Na + /Ca 2+ exchanger in smooth muscle function. Here, we first review those two developments and then apply them to airway smooth muscle and asthma. airway-related disease; airway smooth muscle Address for reprint requests and other correspondence: L. J. Janssen, L-314, St. Joseph's Hospital, 50 Charlton Ave. East, Hamilton, Ontario, Canada L8N 4A6 (e-mail: janssenl{at}mcmaster.ca )
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00379.2007