Impact of optimal glycemic control on the progression of coronary artery calcification in asymptomatic patients with diabetes

• Published in: International journal of cardiology 2018-09, Vol.266, p.250-253
• Main Authors: Won, Ki-Bum, Han, Donghee, Lee, Ji Hyun, Lee, Sang-Eun, Sung, Ji Min, Choi, Su-Yeon, Chun, Eun Ju, Park, Sung Hak, Han, Hae-Won, Sung, Jidong, Jung, Hae Ok, Chang, Hyuk-Jae
• Format: Article
• Language: English
• Subjects: Aged; Asymptomatic Diseases - epidemiology; Blood Glucose - metabolism; Coronary artery calcification; Coronary Artery Disease - blood; Coronary Artery Disease - diagnostic imaging; Coronary Artery Disease - epidemiology; Coronary Vessels - diagnostic imaging; Coronary Vessels - metabolism; Diabetes mellitus; Diabetes Mellitus - blood; Diabetes Mellitus - diagnostic imaging; Diabetes Mellitus - epidemiology; Disease Progression; Female; Glycemic Index - physiology; Humans; Longitudinal Studies; Male; Middle Aged; Optimal glycemic control; Registries; Retrospective Studies; Vascular Calcification - blood; Vascular Calcification - diagnostic imaging; Vascular Calcification - epidemiology
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2018.03.112

Data on the impact of optimal glycemic control (OGC) on the progression of coronary artery calcification, an important marker for future adverse cardiovascular events in individuals with diabetes are limited. We investigated 1637 asymptomatic adults with diabetes (56 ± 8 years, 88.8% men) and no history of coronary artery disease or stroke, who underwent serial coronary artery calcium (CAC) screening. The median inter-scan period was 3.0 (2.0–4.4) years. The change in CAC was compared base on OGC status. OGC was defined as a follow-up hemoglobin A1C (HbA1C) of