A Role for Presenilin 1 in Regulating the Delivery of Amyloid Precursor Protein to the Cell Surface

Presenilin 1 (PS1) and presenilin 2 play a critical role in the γ-secretase processing of amyloid precursor protein (APP) and Notch1. Here, we investigate maturation and intracellular trafficking of APP and other membrane proteins in cells expressing an experimental PS1 deletion mutant (ΔM1,2). Stab...

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Bibliographic Details
Published in:Neurobiology of disease 2002-10, Vol.11 (1), p.64-82
Main Authors: Leem, Jae Yoon, Saura, Carlos A., Pietrzik, Claus, Christianson, John, Wanamaker, Christian, King, LaShaunda T., Veselits, Margaret L., Tomita, Taisuke, Gasparini, Laura, Iwatsubo, Takeshi, Xu, Huaxi, Green, William N., Koo, Edward H., Thinakaran, Gopal
Format: Article
Language:English
Subjects:
acetylcholine receptors
Alzheimer's disease
Amyloid beta-Peptides - metabolism
Amyloid beta-Peptides - secretion
Amyloid beta-Protein Precursor - metabolism
Amyloid beta-Protein Precursor - secretion
Amyloid Precursor Protein Secretases
Animals
APP
Aspartic Acid Endopeptidases
Cells, Cultured
Endopeptidases - metabolism
Gene Deletion
Gene Expression
Glycosylation
Humans
Membrane Glycoproteins - metabolism
Membrane Proteins - chemistry
Membrane Proteins - genetics
Membrane Proteins - metabolism
nicastrin
Peptide Fragments - metabolism
Peptide Fragments - secretion
Presenilin-1
Presenilin-2
Protein Structure, Tertiary
Protein Transport - physiology
PS1
Receptors, Nicotinic - genetics
Receptors, Nicotinic - metabolism
γ-secretase
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