Synthesis of isoxazolidines by 1,3-dipolar cycloaddition and their bioactivity

A series of new isoxazolidines was prepared by 1,3-dipolar cycloaddition of different mono-substituted styrenes with 1,3-dipolar compounds that were prepared by the reaction of N-methylhydroxylamine sulfate with aromatic carbonyl substances. This synthetic pathway for the preparation of isoxazolidin...

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Bibliographic Details
Published in:Frontiers of chemistry in China 2006-12, Vol.1 (4), p.427-433
Main Authors: Cheng, Chunsheng, Li, Zhinian, Shu, Jinyan, Li, Tao, Zhang, Baoyan
Format: Article
Language:English
Subjects:
Botrytis cinerea
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Summary:A series of new isoxazolidines was prepared by 1,3-dipolar cycloaddition of different mono-substituted styrenes with 1,3-dipolar compounds that were prepared by the reaction of N-methylhydroxylamine sulfate with aromatic carbonyl substances. This synthetic pathway for the preparation of isoxazolidines was an ideal process of green chemistry. The synthetic products were 5-substituted isoxazolidines and their structures were characterized by mass and NMR (H-, C-, COSY, HSQC, and DEPT) spectrometry, and their bioactivity was investigated indicating that some new compounds inhibited Botrytis cinerea effectively.
ISSN:1673-3495
1673-3614
DOI:10.1007/s11458-006-0068-z