Traffic-related air pollution and eczema in the elderly: Findings from the SALIA cohort

•High prevalence and incidence of eczema symptoms in women over 55 years of age.•Association between air pollution and incidence of eczema after an age of 55 years.•Indications that the AHR signaling pathway might be involved in this association. Childhood eczema results from an interplay of genetic...

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Bibliographic Details
Published in:International journal of hygiene and environmental health 2018-07, Vol.221 (6), p.861-867
Main Authors: Schnass, Winnie, Hüls, Anke, Vierkötter, Andrea, Krämer, Ursula, Krutmann, Jean, Schikowski, Tamara
Format: Article
Language:English
Subjects:
Adults
Aged
Air Pollutants - adverse effects
Air Pollutants - analysis
Atopic dermatitis
Cohort Studies
Eczema - epidemiology
Eczema - genetics
Eczema symptoms
Female
Germany - epidemiology
Humans
Incidence
Late onset
Nitrogen Oxides - adverse effects
Nitrogen Oxides - analysis
Particulate Matter - adverse effects
Particulate Matter - analysis
Polymorphism, Single Nucleotide
Prevalence
Receptors, Aryl Hydrocarbon - genetics
Traffic-Related Pollution - adverse effects
Traffic-Related Pollution - analysis
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Summary:•High prevalence and incidence of eczema symptoms in women over 55 years of age.•Association between air pollution and incidence of eczema after an age of 55 years.•Indications that the AHR signaling pathway might be involved in this association. Childhood eczema results from an interplay of genetic and environmental factors including Traffic-Related Air Pollution (TRAP). In contrast, little is known about eczema in the elderly in general and its association with TRAP in particular. Animal experiments indicate that the arylhydrocarbon receptor (AHR) might link TRAP and eczema. We investigated (i) incidence and prevalence of eczema in elderly women, (ii) its association with long-term TRAP exposure and (iii) the effect modification by AHR polymorphism rs2066853. The study is based on the SALIA cohort. The women’s average age was 55 years at baseline (1985–1994) and 74 years at follow-up (2008–2009) examination. Incidence and prevalence of eczema were assessed by an adapted version of the International Study of Asthma and Allergies in Childhood (ISAAC) symptom questionnaire. TRAP was determined using land-use regression models. Adjusted logistic regression models were used. After age 55, the incidence and prevalence of eczema symptoms were 7.9% and 8.8%, respectively. Significant associations (p 
ISSN:1438-4639
1618-131X
DOI:10.1016/j.ijheh.2018.06.002