A bright FIT-PNA hybridization probe for the hybridization state specific analysis of a C—> U RNA edit via FRET in a binary system

Oligonucleotide probes that show enhanced fluorescence upon nucleic acid hybridization enable the detection and visualization of specific mRNA molecules, in vitro and in cellulo . A challenging problem is the analysis of single nucleotide alterations that occur, for example, when cellular mRNA is su...

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Bibliographic Details
Published in:Chemical science (Cambridge) 2018, Vol.9 (21), p.4794-4800
Main Authors: Fang, Ge-min, Chamiolo, Jasmine, Kankowski, Svenja, Hövelmann, Felix, Friedrich, Dhana, Löwer, Alexander, Meier, Jochen C., Seitz, Oliver
Format: Article
Language:English
Subjects:
Alignment
Chemistry
Emission
Fluorescence
Glycine
Hybridization
Molecular chains
Ribonucleic acid
RNA
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