Intestinal decontamination improves liver haemodynamics in patients with alcohol‐related decompensated cirrhosis

Summary Background  Endotoxaemia is commonly seen in cirrhotic patients with ascites and this may be associated with increased portal pressure. Aim  To investigate the effect of intestinal decontamination on liver haemodynamics in alcohol‐related cirrhotic patients with ascites. Methods  We included...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2009-05, Vol.29 (9), p.992-999
Main Authors: VLACHOGIANNAKOS, J., SAVERIADIS, A. S., VIAZIS, N., THEODOROPOULOS, I., FOUDOULIS, K., MANOLAKOPOULOS, S., RAPTIS, S., KARAMANOLIS, D. G.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alcohol-Related Disorders
Alcoholism and acute alcohol poisoning
Anti-Infective Agents - therapeutic use
Ascites - drug therapy
Biological and medical sciences
Digestive system
Endotoxins - metabolism
Epidemiology. Vaccinations
Female
Gastroenterology. Liver. Pancreas. Abdomen
General aspects
Humans
Infectious diseases
Liver Circulation - drug effects
Liver Cirrhosis - blood
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
Pharmacology. Drug treatments
Rifamycins - administration & dosage
Toxicology
Treatment Outcome
Venous Pressure - drug effects
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Summary:Summary Background  Endotoxaemia is commonly seen in cirrhotic patients with ascites and this may be associated with increased portal pressure. Aim  To investigate the effect of intestinal decontamination on liver haemodynamics in alcohol‐related cirrhotic patients with ascites. Methods  We included 30 patients. At day 0, systemic and splanchnic circulation endotoxin levels were determined and HVPG measurement performed. Patients received rifaximin (1200 mg/day) for 28 days. At day 29, systemic and splanchnic circulation endotoxin levels were determined and HVPG measurement performed again. Results  Median (range) plasma endotoxin levels decreased significantly after rifaximin administration both in systemic [1.45(0–3.1) vs. 0.7(0–2.7), P 
ISSN:0269-2813
1365-2036
DOI:10.1111/j.1365-2036.2009.03958.x