Low-dose aspirin is associated with reduced spontaneous preterm birth in nulliparous women

Preterm birth is one of the leading causes of perinatal morbidity and mortality. Clinical data suggest that low-dose aspirin may decrease the rate of overall preterm birth, but investigators have speculated that this is likely due to a decrease in medically indicated preterm birth through its effect...

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Bibliographic Details
Published in:American journal of obstetrics and gynecology 2018-10, Vol.219 (4), p.399.e1-399.e6
Main Authors: Andrikopoulou, Maria, Purisch, Stephanie E., Handal-Orefice, Roxane, Gyamfi-Bannerman, Cynthia
Format: Article
Language:English
Subjects:
Administration, Oral
Adolescent
Aspirin - administration & dosage
Aspirin - therapeutic use
Female
Gestational Age
Humans
low-dose aspirin
nulliparous
Parity
placental disease
platelet aggregation
Platelet Aggregation Inhibitors - administration & dosage
Platelet Aggregation Inhibitors - therapeutic use
Pre-Eclampsia - drug therapy
preeclampsia
Pregnancy
Premature Birth - prevention & control
preterm birth
spontaneous preterm birth
Treatment Outcome
uteroplacental ischemia
Young Adult
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Summary:Preterm birth is one of the leading causes of perinatal morbidity and mortality. Clinical data suggest that low-dose aspirin may decrease the rate of overall preterm birth, but investigators have speculated that this is likely due to a decrease in medically indicated preterm birth through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low-dose aspirin may also have an impact on the mechanism of spontaneous preterm labor. Our objective was to determine whether low-dose aspirin reduces the rate of spontaneous preterm birth in nulliparous women without medical comorbidities. This is a secondary analysis of a randomized, placebo-controlled trial of low-dose aspirin for the prevention of preeclampsia in healthy, low-risk, nulliparous women. Low-risk women were defined by the absence of hypertension, renal disease, diabetes, other endocrine disorders, seizures, heart disease, or collagen vascular disease. Our study was limited to singleton, nonanomalous gestations. Women were eligible if they had prior pregnancy terminations but not prior spontaneous pregnancy loss
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2018.06.011