Enzymes as Green Catalysts and Interactive Biomolecules in Wound Dressing Hydrogels

Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bon...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2018-10, Vol.36 (10), p.1040-1053
Main Authors: Guebitz, Georg M., Nyanhongo, Gibson S.
Format: Article
Language:English
Subjects:
Bandages
bioactive molecules
Biomolecules
Catalysis
Catalysts
Cell adhesion & migration
Cell growth
Cellulase
Chemical synthesis
Collagen
Covalent bonds
Diagnostic systems
E coli
Enzymes
Enzymes - administration & dosage
Green Chemistry Technology - methods
Growth factors
Hydrogel, Polyethylene Glycol Dimethacrylate - administration & dosage
Hydrogels
Infections
Mechanical properties
Microorganisms
Organic chemistry
Peptides
Polymers
Proteins
synthesis
Technology, Pharmaceutical - methods
Tensile strength
wound dressing hydrogels
Wound healing
Wounds and Injuries - therapy
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Summary:Hydrogels are 3D hydrophilic polymer networks that absorb and hold huge amounts of water. Although hydrogels have traditionally been synthesized using chemical and physical methods, rapid developments in enzyme technology that, like chemical-based methods, enable the formation of stable covalent bonds are fast emerging as alternative ‘green catalyst’ tools. Enzymes show great potential for the synthesis of complex multifunctional wound dressing hydrogels (WDHs) ex situ and in situ as well as in acting as interactive molecules to promote the wound healing process. This review presents advances in the use of enzymes to synthesize WDHs and their fascinating role as bioactive molecules promoting the wound healing process, preventing microbial infection, and providing in situ, in-built infection-detection and diagnostic systems. Enzymes are versatile catalysts for ex situ and in situ synthesis of wound dressing hydrogels (WDHs). Enzymes in WDH prevent microbial infection and colonization of the wound. Enzymes as bioactive molecules in WDHs promote wound healing. Enzymes can serve as in situ microbial infection and diagnostic systems in WDHs.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2018.05.006