A quantitative study on the chemical composition of renal stones and their fluoride content from Anantapur District, Andhra Pradesh, India

The present study was designed to investigate and arrive at the quantitative chemical composition, inclusive of fluoride content, of 56 kidney stone (renal calculi) samples from 50 patients aged between 20 and 60 years, admitted to Sri Sathya Sai Institute of Higher Medical Sciences Hospital, Prasan...

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Bibliographic Details
Published in:Current science (Bangalore) 2008-01, Vol.94 (1), p.104-109
Main Authors: Sathish, R. Sai, Ranjit, B., Ganesh, K. M., Rao, G. Nageswara, Janardhana, C.
Format: Article
Language:English
Subjects:
Calcium
Chemical composition
Fluorides
Groundwater
Kidney stones
Nephrolithiasis
Oxalates
RESEARCH COMMUNICATIONS
Stone
Uric acid
Urinary calculi
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Summary:The present study was designed to investigate and arrive at the quantitative chemical composition, inclusive of fluoride content, of 56 kidney stone (renal calculi) samples from 50 patients aged between 20 and 60 years, admitted to Sri Sathya Sai Institute of Higher Medical Sciences Hospital, Prasanthigram, Anantapur District, Andhra Pradesh. Analysis of the calculi was performed using Fourier Transform Infrared vibrational spectroscopic method along with Differential Scanning Calorimetry and the Fluoride Ion Selective Electrode. These are the preferred instrumental techniques with the inherent advantages of providing fast, sensitive, accurate and detailed data about the stone composition, enabling more reliable and efficient post-operative care of individual patients. The results indicate that calcium oxalate monohydrate (whewellite) and dihydrate (wedellite) stones are predominant in this region of Anantapur, with the binary combination of the two accounting for 90% of the stone composition in nearly 85% of the stones, with traces of carbonate–hydroxyapatite (dahllite) or uric acid being the ternary component. In the remaining 15% of the stones, uric acid was the major component. The mean fluoride content in renal calculi was determined to be 2.14 mg/g. A quantitative understanding of the exact chemical composition of the urinary calculi is of importance not only because of its relationship with dietary and other health factors, but also in prevention of nephrolithiasis.
ISSN:0011-3891