White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or...

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Bibliographic Details
Published in:Frontiers of medicine 2019-12, Vol.13 (6), p.741-746
Main Authors: Liu, Jian, Shen, Pingyan, Ma, Xiaobo, Yu, Xialian, Ni, Liyan, Hao, Xu, Wang, Weiming, Chen, Nan
Format: Article
Language:English
Subjects:
Adult
Aged
China - epidemiology
chronic kidney disease
Cross-Sectional Studies
Female
Humans
hyperuricemia
Hyperuricemia - blood
Hyperuricemia - complications
Hyperuricemia - epidemiology
Incidence
Inflammation
Kidney diseases
Letter to Frontiers of Medicine
Leukocyte Count
Leukocytes
Logistic Models
Male
Medicine
Medicine & Public Health
Middle Aged
Multivariate Analysis
Prevalence
Renal Insufficiency, Chronic - blood
Renal Insufficiency, Chronic - complications
Renal Insufficiency, Chronic - epidemiology
Risk Factors
white blood cell count
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Summary:Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m 2). HUA was defined as serum uric acid>420 µmol/L in men and>360 µmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α , and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.
ISSN:2095-0217
2095-0225
DOI:10.1007/s11684-017-0579-7