Photocontrol of Drug Release from Supramolecular Hydrogels with Green Light

Photoresponsive smart materials transform light energy into sophisticated functions. They find increasing biomedical applications in light‐induced drug‐release and photopharmacology, because they can provide the desired therapeutic effect locally due to precise spatiotemporal dosage control. However...

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Bibliographic Details
Published in:Chemistry : a European journal 2018-08, Vol.24 (45), p.11605-11610
Main Authors: Karcher, Johannes, Pianowski, Zbigniew L.
Format: Article
Language:English
Subjects:
Antibiotics
Biomedical materials
Chemistry
Cytotoxicity
drug delivery
Drug delivery systems
gels
Hydrogels
Inflammation
Low molecular weights
Molecular weight
photochromism
Smart materials
sol-gel processes
supramolecular chemistry
Ultraviolet radiation
Weight reduction
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Summary:Photoresponsive smart materials transform light energy into sophisticated functions. They find increasing biomedical applications in light‐induced drug‐release and photopharmacology, because they can provide the desired therapeutic effect locally due to precise spatiotemporal dosage control. However, the majority of reported studies rely on cytotoxic UV light that penetrates tissues poorly. Here, we report the first drug‐releasing system based on photochromic low molecular weight supramolecular hydrogels that is triggered with visible light. We demonstrated green‐light‐induced release of structurally unmodified antibiotic, anticancer, and anti‐inflammatory drugs under physiological conditions. Using the antibiotic‐loaded gel, we selectively inhibited bacterial growth with green light. Go green! Supramolecular hydrogels based on photochromic cyclic dipeptides reversibly dissipate with green light (see figure). They can release encapsulated antibiotic, anticancer and anti‐inflammatory drugs. Selective inhibition of bacterial growth with green light is demonstrated using the gel filled with an antibiotic.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201802205