Co-Occurrence of IgA Antibodies Against Ethanol Metabolites and Tissue Transglutaminase in Alcohol Consumers: Correlation with Proinflammatory Cytokines and Markers of Fibrogenesis

IgA antibodies to tissue transglutaminase have been suggested to be specific indicators of celiac disease. However, no studies have addressed the relationships between such antibodies and alcohol abuse, which is also a common cause of IgA-isotype immune responses and tissue injury in the gastrointes...

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Bibliographic Details
Published in:Digestive diseases and sciences 2008-02, Vol.53 (2), p.500-505
Main Authors: Koivisto, Heidi, Hietala, Johanna, Anttila, Petra, Niemelä, Onni
Format: Article
Language:English
Subjects:
Adult
Alcoholism - immunology
Biochemistry
Biological and medical sciences
Ethanol - metabolism
Female
Gastroenterology
Gastroenterology. Liver. Pancreas. Abdomen
GTP-Binding Proteins
Hepatology
Humans
Immune Tolerance - immunology
Immunity, Mucosal
Immunoglobulin A - immunology
Intestinal Mucosa - immunology
Liver Diseases, Alcoholic - immunology
Male
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Oncology
Original Paper
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Transglutaminases - immunology
Transplant Surgery
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Summary:IgA antibodies to tissue transglutaminase have been suggested to be specific indicators of celiac disease. However, no studies have addressed the relationships between such antibodies and alcohol abuse, which is also a common cause of IgA-isotype immune responses and tissue injury in the gastrointestinal tract and liver. Here, measurements of specific IgAs against tissue transglutaminase and proteins modified by acetaldehyde, the first metabolite of ethanol, showed significantly higher levels of both antibodies in alcoholic liver disease patients than in healthy controls or heavy drinkers without liver disease. These antibodies also significantly co-occurred in heavy drinkers without liver disease, moderate drinkers, and abstainers, and correlated with biomarkers of alcohol consumption, proinflammatory cytokines and markers of fibrogenesis. The data suggests a link between such immune responses, perturbations in cytokine profiles and fibrogenesis, which should be implicated in studies on the pathogenesis and diagnosis of ethanol-induced tissue injury and celiac disease.
ISSN:0163-2116
1573-2568
DOI:10.1007/s10620-007-9874-5