Subacute oral toxicity study of di(2-ethylhexyl)adipate based on the draft protocol for the Enhanced OECD Test Guideline no. 407

We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses o...

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Bibliographic Details
Published in:Archives of toxicology 2006-04, Vol.80 (4), p.181-186
Main Authors: MIYATA, Katsumi, SHIRAISHI, Keiji, HOUSHUYAMA, Satsuki, IMATANAKA, Nobuya, UMANO, Takaaki, MINOBE, Yasushi, YAMASAKI, Kanji
Format: Article
Language:English
Subjects:
Adipates - toxicity
Administration, Oral
Animal reproduction
Animals
Biological and medical sciences
Blood Cell Count
Body Weight - drug effects
Eating - drug effects
Estrous Cycle - drug effects
Female
Food Additives - toxicity
Hormones - blood
Male
Medical sciences
Organ Size - drug effects
Plasticizers - toxicity
Rats
Rats, Sprague-Dawley
Rodents
Sperm Count
Toxicology
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Summary:We performed a 28-day repeated-dose toxicity study of di(2-ethylhexyl)adipate (DEHA) based on the draft protocol of the "Enhanced OECD Test Guideline 407" to investigate whether it has endocrine-mediated properties according to this assay. DEHA was orally administered to SD rats at doses of 0, 40, 200 and 1,000 mg/kg/day for at least 28 days, and disturbance of the estrous cycle and increased ovarian follicle atresia were detected in the 1,000 mg/kg group.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-005-0030-8