Cordyceps cicadae mycelia and its active compound HEA exert beneficial effects on blood glucose in type 2 diabetic db/db mice

BACKGROUND This is the first study to investigate the therapeutic effects of Cordyceps cicadae (C. cicadae) mycelia and its active compound N6‐(2‐hydroxyethyl)adenosine (HEA) on blood glucose in genetically diabetic mice. RESULTS Forty mice, 9 weeks of age, were divided into normal control, diabetic...

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Bibliographic Details
Published in:Journal of the science of food and agriculture 2019-01, Vol.99 (2), p.606-612
Main Authors: Li, I‐Chen, Lin, Shan, Tsai, Yueh‐Ting, Hsu, Jui‐Hsia, Chen, Yen‐Lien, Lin, Wen‐Hsin, Chen, Chin‐Chu
Format: Article
Language:English
Subjects:
Adenosine
Animals
Blood
Blood glucose
Blood Glucose - metabolism
blood‐sugar regulation
Complications
Cordyceps
Cordyceps - chemistry
Cordyceps cicadae mycelia
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - metabolism
diabetic model
Dietary supplements
Glucose
Glucose tolerance
Glucose Tolerance Test
Homeostasis
Humans
Insulin
Insulin - metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mycelia
Mycelium - chemistry
N6‐(2‐hydroxyethyl)adenosine
Organic chemistry
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Summary:BACKGROUND This is the first study to investigate the therapeutic effects of Cordyceps cicadae (C. cicadae) mycelia and its active compound N6‐(2‐hydroxyethyl)adenosine (HEA) on blood glucose in genetically diabetic mice. RESULTS Forty mice, 9 weeks of age, were divided into normal control, diabetic control, and three C. cicadae mycelia treated diabetic groups. After 9 weeks of continuous supplementation, the oral glucose tolerance test (OGTT) and homeostasis model of assessment‐insulin resistance index showed significant glucose tolerance with C. cicadae mycelia. Furthermore, the effect of HEA is similar to that of C. cicadae mycelia in an OGTT, suggesting that HEA could be the major factor responsible for the functional properties of C. cicadae mycelia. CONCLUSION Based on these findings, it is suggested that the therapeutic effect of C. cicadae mycelia may be driven by one of its active components, HEA, which could alleviate many diabetes complications in genetically obese mice and may offer promise as a supplement for diabetes management. © 2018 Society of Chemical Industry
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.9221