Circulating insulin-like peptide 5 levels and its association with metabolic and hormonal parameters in women with polycystic ovary syndrome

Purpose Insulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is inv...

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Bibliographic Details
Published in:Journal of endocrinological investigation 2019-03, Vol.42 (3), p.303-312
Main Authors: Bicer, M., Alan, M., Alarslan, P., Guler, A., Kocabas, G. U., Imamoglu, C., Aksit, M., Bozkaya, G., Isil, A. M., Baloglu, A., Aslanipoiur, B., Calan, Mehmet
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Body Mass Index
Body weight
Carotid Intima-Media Thickness
Case-Control Studies
Cross-Sectional Studies
Endocrinology
Enzyme-linked immunosorbent assay
Female
Follow-Up Studies
Food intake
Homeostasis
Hormones - metabolism
Humans
Insulin
Insulin - blood
Insulin Resistance
Luteinizing hormone
Medicine
Medicine & Public Health
Metabolic Diseases
Metabolic Diseases - blood
Metabolic Diseases - diagnosis
Metabolic Diseases - etiology
Metabolism
Middle Aged
Obesity - physiopathology
Original Article
Overweight
Peptides
Polycystic ovary syndrome
Polycystic Ovary Syndrome - complications
Prognosis
Proteins
Relaxin
Reproductive system
ROC Curve
Ultrasound
Young Adult
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Summary:Purpose Insulin-like peptide 5 (INSL5) is a gut peptide hormone that is a member of relaxin/insulin superfamily. Growing evidence implicates the crucial role of the peptide in some metabolisms including food intake, glucose homeostasis and reproductive system. Polycystic ovary syndrome (PCOS) is involved in both reproductive and metabolic issues. The aim of the study was determination of circulating levels of INSL5 alteration in women with PCOS and evaluation of the relationship between INSL5 and hormonal-metabolic parameters as well as carotid intima media thickness (cIMT). Methods A total of 164 subjects were recruited in this cross-sectional study (82 women with PCOS and 82 age- and BMI-matched controls). Circulating INSL5 levels were assessed via ELISA method. High-resolution B-mode ultrasound was used to measure cIMT. The hormonal and metabolic parameters of the recruited subjects were determined. Results Circulating INSL5 levels were significantly elevated in women with PCOS compared to controls (27.63 ± 7.74 vs. 19.90 ± 5.85 ng/ml, P  
ISSN:1720-8386
0391-4097
1720-8386
DOI:10.1007/s40618-018-0917-x