Prevalence of sarcopenia in systemic sclerosis: assessing body composition and functional disability in patients with systemic sclerosis

•Sarcopenia is prevalent in patients with systemic sclerosis.•Sarcopenia is more prevalent in systemic sclerosis than otherwise found in a comparable age group.•Sarcopenic patients with systemic sclerosis suffer from impaired functional status. We analyzed the prevalence of sarcopenia among systemic...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2018-11, Vol.55-56, p.51-55
Main Authors: Siegert, Elise, March, Christine, Otten, Lindsey, Makowka, Alexander, Preis, Emelina, Buttgereit, Frank, Riemekasten, Gabriela, Müller-Werdan, Ursula, Norman, Kristina
Format: Article
Language:English
Subjects:
Age
Bioelectricity
Body composition
Body mass index
Chronic illnesses
Comorbidity
Disease
Drugs
Immunosuppressive agents
Knee
Malnutrition
Muscle strength
Muscles
Older people
Patients
Physical function
Quality of life
Risk analysis
Risk factors
Sarcopenia
Scleroderma
Systemic sclerosis
Womens health
Young adults
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Summary:•Sarcopenia is prevalent in patients with systemic sclerosis.•Sarcopenia is more prevalent in systemic sclerosis than otherwise found in a comparable age group.•Sarcopenic patients with systemic sclerosis suffer from impaired functional status. We analyzed the prevalence of sarcopenia among systemic sclerosis (SSc) patients with respect to quality of life, disability, organ involvement, and muscle function. A total of 129 patients who met the ACR/EULAR 2013 classification criteria were included. Body composition was measured using bioelectric impedance analysis. Sarcopenia was defined according to the criteria of the European Working Group on Sarcopenia in Older People. Handgrip and knee extension strength and pulmonary peak flow were measured. Physical function was assessed with the Short Form-36 Health Survey and Scleroderma Health Assessment Questionnaire. Sarcopenia was prevalent in 22.5% of patients. There were significant differences between patients with and without sarcopenia regarding handgrip strength (11.5 [2.0–30.0] versus 18.0 [1.0–41.0] kilogram force [kgf]; P 
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2018.03.046