Combining Acoustic Trapping With Plane Wave Imaging for Localized Microbubble Accumulation in Large Vessels

The capability of accumulating microbubbles using ultrasound could be beneficial for enhancing targeted drug delivery. When microbubbles are used to deliver a therapeutic payload, there is a need to track them, for a localized release of the payload. In this paper, a method for localizing microbubbl...

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Bibliographic Details
Published in:IEEE transactions on ultrasonics, ferroelectrics, and frequency control ferroelectrics, and frequency control, 2018-07, Vol.65 (7), p.1193-1204
Main Authors: Luzhen Nie, Harput, Sevan, Cowell, David M. J., Carpenter, Thomas M., Mclaughlan, James R., Freear, Steven
Format: Article
Language:English
Subjects:
Acoustic beams
Acoustic radiation force (ARF)
acoustic trap
Acoustics
atherosclerosis
diagnostic ultrasound
Force
Frequency control
Magnetic resonance imaging
microbubbles
plane wave imaging (PWI)
sonothrombolysis
targeted drug delivery
Ultrasonic imaging
ultrasound contrast agents
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Summary:The capability of accumulating microbubbles using ultrasound could be beneficial for enhancing targeted drug delivery. When microbubbles are used to deliver a therapeutic payload, there is a need to track them, for a localized release of the payload. In this paper, a method for localizing microbubble accumulation with fast image guidance is presented. A linear array transducer performed trapping of microbubble populations interleaved with plane wave imaging, through the use of a composite pulse sequence. The acoustic trap in the pressure field was created parallel with the direction of flow in a model of a vessel section. The acoustic trapping force resultant from the large gradients in the acoustic field was engendered to directly oppose the flowing microbubbles. This was demonstrated numerically with field simulations, and experimentally using an Ultrasound Array Research Platform II. SonoVue microbubbles at clinically relevant concentrations were pumped through a tissue-mimicking flow phantom and exposed to either the acoustic trap or a control ultrasonic field composed of a single-peak acoustic radiation force beam. Under the flow condition at a shear rate of 433 s -1 , the use of the acoustic trap led to lower speed estimations (p
ISSN:0885-3010
1525-8955
DOI:10.1109/TUFFC.2018.2838332