Protection from radiation-induced pneumonitis using cerium oxide nanoparticles

Abstract In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO2 ) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerati...

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Bibliographic Details
Published in:Nanomedicine 2009-06, Vol.5 (2), p.225-231
Main Authors: Colon, Jimmie, MS, Herrera, Luis, MD, Smith, Joshua, BS, Patil, Swanand, PhD, Komanski, Chris, BS, Kupelian, Patrick, MD, Seal, Sudipta, PhD, Jenkins, D. Wayne, MD, Baker, Cheryl H., PhD
Format: Article
Language:English
Subjects:
Animals
Cerium - administration & dosage
Cerium - chemistry
Dose-Response Relationship, Drug
Free Radical Scavengers - administration & dosage
Free Radical Scavengers - chemistry
Internal Medicine
Mice
Mice, Nude
Nanoparticles
Nanoparticles - administration & dosage
Nanoparticles - chemistry
Pneumonitis
Quality of life
Radiation Pneumonitis - prevention & control
Radiation-Protective Agents - administration & dosage
Radiation-Protective Agents - chemistry
Radioprotection
Reactive Oxygen Species - metabolism
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Summary:Abstract In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO2 ) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO2 nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO2 nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy.
ISSN:1549-9634
1549-9642
DOI:10.1016/j.nano.2008.10.003