NF-κB Is a Key Mediator of Cerebral Aneurysm Formation

• Published in: Circulation (New York, N.Y.) N.Y.), 2007-12, Vol.116 (24), p.2830-2840
• Main Authors: AOKI, Tomohiro, KATAOKA, Hiroharu, SHIMAMURA, Munehisa, NAKAGAMI, Hironori, WAKAYAMA, Kouji, MORIWAKI, Takuya, ISHIBASHI, Ryota, NOZAKI, Kazuhiko, MORISHITA, Ryuichi, HASHIMOTO, Nobuo
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Blood and lymphatic vessels; Cardiology. Vascular system; Diseases of the aorta; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Nervous system; Radiodiagnosis. Nmr imagery. Nmr spectrometry
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/CIRCULATIONAHA.107.728303

Background— Subarachnoid hemorrhage caused by the rupture of cerebral aneurysm (CA) remains a life-threatening disease despite recent diagnostic and therapeutic advancements. Recent studies strongly suggest the active participation of macrophage-mediated chronic inflammatory response in the pathogenesis of CA. We examined the role of nuclear factor-κB (NF-κB) in the pathogenesis of CA formation in this study. Methods and Results— In experimentally induced CAs in rats, NF-κB was activated in cerebral arterial walls in the early stage of aneurysm formation with upregulated expression of downstream genes. NF-κB p50 subunit–deficient mice showed a decreased incidence of CA formation with less macrophage infiltration into the arterial wall. NF-κB decoy oligodeoxynucleotide also prevented CA formation when it was administered at the early stage of aneurysm formation in rats. Macrophage infiltration and expression of downstream genes were dramatically inhibited by NF-κB decoy oligodeoxynucleotide. In human CA walls, NF-κB also was activated, especially in the intima. Conclusions— Our data indicate that NF-κB plays a crucial role as a key regulator in the initiation of CA development by inducing some inflammatory genes related to macrophage recruitment and activation. NF-κB may represent a therapeutic target of a novel medical treatment for CA.