Persistent reduction of conduction velocity and myelinated axon damage in vibrated rat tail nerves

Prolonged hand‐transmitted vibration exposure in the workplace has been recognized for almost a century to cause neurodegenerative and vasospastic disease. Persistence of the diseased state for years after cessation of tool use is of grave concern. To understand persistence of vibration injury, the...

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Bibliographic Details
Published in:Muscle & nerve 2009-06, Vol.39 (6), p.770-775
Main Authors: Loffredo, Michael A., Yan, Ji-Geng, Kao, Dennis, Zhang, Lin Ling, Matloub, Hani S., Riley, Danny A.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
demyelination
Disease Models, Animal
Diseases of striated muscles. Neuromuscular diseases
Electric Stimulation
Electrodiagnosis
hand-arm vibration syndrome
Hand-Arm Vibration Syndrome - physiopathology
Male
Medical sciences
nerve edema
Nerve Fibers, Myelinated - pathology
Nerve Fibers, Myelinated - physiology
Neural Conduction - physiology
Neurology
occupational Raynaud disease
peripheral nerve
Peripheral Nerves - pathology
Peripheral Nerves - physiopathology
Rats
Rats, Sprague-Dawley
Reaction Time - physiology
Tail - innervation
Tail - physiopathology
Time Factors
Vibration - adverse effects
Wallerian Degeneration - etiology
Wallerian Degeneration - pathology
Wallerian Degeneration - physiopathology
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Summary:Prolonged hand‐transmitted vibration exposure in the workplace has been recognized for almost a century to cause neurodegenerative and vasospastic disease. Persistence of the diseased state for years after cessation of tool use is of grave concern. To understand persistence of vibration injury, the present study examined recovery of nerve conduction velocity and structural damage of myelinated axons in a rat tail vibration model. Both 7 and 14 days of vibration (4 h/day) decreased conduction velocity. The decrease correlated directly with the increased percentage of disrupted myelinated axons. The total number of myelinated axons was unchanged. During 2 months of recovery, conduction velocity returned to control level after 7‐day vibration but remained decreased after 14‐day vibration. The rat tail model provides insight into understanding the persistence of neural deficits in hand–arm vibration syndrome. Muscle Nerve, 2009
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.21235