Adherence to Mediterranean diet, high-sensitive C-reactive protein, and severity of coronary artery disease: Contemporary data from the INTERCATH cohort

Guidelines recommend a healthy diet as a cornerstone of cardiovascular disease (CVD) prevention. Although the Mediterranean diet (MD) is the best studied dietary pattern for CV outcomes, data on association between MD and severity of CAD are limited. Therefore, we analysed dietary data in associatio...

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Published in:Atherosclerosis 2018-08, Vol.275, p.256-261
Main Authors: Waldeyer, Christoph, Brunner, Fabian J., Braetz, Julian, Ruebsamen, Nicole, Zyriax, Birgit-Christiane, Blaum, Christopher, Kroeger, Friederike, Kohsiack, Rebecca, Schrage, Benedikt, Sinning, Christoph, Becher, Peter M., Karakas, Mahir, Zeller, Tanja, Westermann, Dirk, Sydow, Karsten, Blankenberg, Stefan, Seiffert, Moritz, Schnabel, Renate B.
Format: Article
Language:English
Subjects:
Coronary artery disease
hs-CRP
Mediterranean diet
SYNTAX score
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Summary:Guidelines recommend a healthy diet as a cornerstone of cardiovascular disease (CVD) prevention. Although the Mediterranean diet (MD) is the best studied dietary pattern for CV outcomes, data on association between MD and severity of CAD are limited. Therefore, we analysed dietary data in association with the SYNTAX score in coronary artery disease (CAD) patients from the INTERCATH study. The INTERCATH study is an observational study in patients undergoing coronary angiography at the University Heart Center Hamburg. Coronary morphology is assessed by the SYNTAX score. A lifestyle questionnaire collects dietary data with food frequency questions at baseline. Based on seven dietary characteristics, we calculated an established Mediterranean diet score (MDS) with a range of 0–28 points at which 28 points reflect maximal adherence to MD. To investigate the association of MD with severity of CAD, we performed logistic regression analysis after adjustment for confounding factors. Of 1121 patients, 27% were women. The median age was 70.7 years (interquartile range (IQR) 61.1,77.0). CV risk factors were distributed as expected for a CAD cohort (31.3% diabetes, 81.1% arterial hypertension, 34.0% smoking, median BMI 26.6 kg/m2 (IQR 24.1, 30.3), median LDL-C 87 mg/dL (IQR 65.0,116,6). Of all variables included, the strongest correlation with MDS was found for log (hs-CRP) (r = −0.21, p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2018.06.877