Modulation of mitochondrial functions by xenobiotic-induced microRNA: From environmental sentinel organisms to mammals

Mitochondria play a crucial role in energetic metabolism, signaling pathways, and overall cell viability. They are in the first line in facing cellular energy requirements in stress conditions, such as in response to xenobiotic exposure. Recently, a novel regulatory key role of microRNAs (miRNAs) in...

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Bibliographic Details
Published in:The Science of the total environment 2018-12, Vol.645, p.79-88
Main Authors: Burgos-Aceves, Mario Alberto, Cohen, Amit, Paolella, Gaetana, Lepretti, Marilena, Smith, Yoav, Faggio, Caterina, Lionetti, Lillà
Format: Article
Language:English
Subjects:
Animals
Environmental Monitoring
Haemocytes
Hepatocytes
Mammals - physiology
microRNA
MicroRNAs
Mitochondria - drug effects
Mitochondria - physiology
Mitochondrial dysfunction
Oxidative Stress
Pollutants
Reactive Oxygen Species
ROS
Sentinel Species
Xenobiotics - toxicity
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Summary:Mitochondria play a crucial role in energetic metabolism, signaling pathways, and overall cell viability. They are in the first line in facing cellular energy requirements in stress conditions, such as in response to xenobiotic exposure. Recently, a novel regulatory key role of microRNAs (miRNAs) in important signaling pathways in mitochondria has been proposed. Consequently, alteration in miRNAs expression by xenobiotics could outcome into mitochondrial dysfunction, reactive oxygen species overexpression, and liberation of apoptosis or necrosis activating proteins. The aim of this review is to show the highlights about mitochondria-associated miRNAs in cellular processes exposed to xenobiotic stress in different cell types involved in detoxification processes or sensitive to environmental hazards in marine sentinel organisms and mammals. [Display omitted] •This review summarizes the current knowledge of miRNA role in condition of xenobiotic exposure.•miRNA in regulating mitochondria and the effect of xenobiotic on mitochondrial function•Modulation of miRNA levels may provide a new therapeutic approach.
ISSN:0048-9697
1879-1026
DOI:10.1016/j.scitotenv.2018.07.109