Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis

Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride sour...

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Bibliographic Details
Published in:Organic letters 2018-08, Vol.20 (15), p.4471-4474
Main Authors: Mo, Jia-Nan, Yu, Wan-Lei, Chen, Jian-Qiang, Hu, Xiu-Qin, Xu, Peng-Fei
Format: Article
Language:English
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Summary:Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the commercially available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analogue of LY503430 was performed to demonstrate the synthetic value of this strategy.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.8b01760