Fate of the Two-Component Lantibiotic Lacticin 3147 in the Gastrointestinal Tract

The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, a...

Full description

Saved in:
Bibliographic Details
Published in:Applied and Environmental Microbiology 2007-11, Vol.73 (21), p.7103-7109
Main Authors: Gardiner, Gillian E, Rea, Mary C, O'Riordan, Brid, O'Connor, Paula, Morgan, Sheila M, Lawlor, Peadar G, Lynch, P. Brendan, Cronin, Michael, Ross, R. Paul, Hill, Colin
Format: Article
Language:English
Subjects:
Bacteriocins - metabolism
Biological and medical sciences
Chymotrypsin - metabolism
Digestive system
Food Microbiology
Fundamental and applied biological sciences. Psychology
Gastrointestinal Tract - metabolism
Microbiology
Peptides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The component peptides of lacticin 3147 were degraded by α-chymotrypsin in vitro with a resultant loss of antimicrobial activity. Activity was also lost in ileum digesta. Following oral ingestion, neither of the lacticin 3147 peptides was detected in the gastric, jejunum, or ileum digesta of pigs, and no lacticin 3147 activity was found in the feces. These observations suggest that lacticin 3147 ingestion is unlikely to have adverse effects, since it is probably inactivated during intestinal transit.
ISSN:0099-2240
1098-5336
DOI:10.1128/AEM.01117-07