Estrogen receptors and sex hormone binding globulin in neuronal cells and tissue

Estrogens exert a critical influence on neuronal tissues and cells. As demonstrated in many clinical studies, estrogens are neuroprotective to the extent that they improve prognosis for women with neurodegenerative diseases. Unfortunately, we still do not know exactly how these effects are mediated....

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Bibliographic Details
Published in:Steroids 2019-02, Vol.142, p.94-99
Main Authors: Gebhart, Veronika M., Caldwell, Jack D., Rodewald, Andrea, Kalyvianaki, Konstantina, Kampa, Marilena, Jirikowski, Gustav F.
Format: Article
Language:English
Subjects:
Animals
Brain - cytology
Brain - metabolism
Estrogen effects
Estrogen receptors
Genomic effect
Humans
Neuronal cells
Neurons - chemistry
Neurons - cytology
Neurons - metabolism
Rapid response to steroids
Rats
Receptors, Estrogen - chemistry
Receptors, Estrogen - metabolism
Sex Hormone-Binding Globulin - chemistry
Sex Hormone-Binding Globulin - metabolism
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Summary:Estrogens exert a critical influence on neuronal tissues and cells. As demonstrated in many clinical studies, estrogens are neuroprotective to the extent that they improve prognosis for women with neurodegenerative diseases. Unfortunately, we still do not know exactly how these effects are mediated. Fifty years ago the first estrogen receptor was found, but since then many other new pathways of estrogen action have been identified. This review describes several of these pathways of estrogen effects and provides some conclusions and correlations about these as determined by recent studies with nerve growth factor differentiated rat pheochromocytoma cell line.
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2018.06.015