Nutritional status, the development and persistence of malnutrition and dietary intake in oesophago‐gastric cancer: a longitudinal cohort study

• Published in: Journal of human nutrition and dietetics 2018-12, Vol.31 (6), p.785-792
• Main Authors: Grace, E. M., Shaw, C., Lalji, A., Mohammed, K., Andreyev, H. J. N., Whelan, K.
• Format: Article
• Language: English
• Subjects: Body weight loss; Cancer; Cohort analysis; Diet; Dietary intake; Females; Food; Food groups; Food intake; gastric; Gastric cancer; gastrointestinal; Gastrointestinal symptoms; Health risks; Males; Malnutrition; Nutrient status; Nutrients; Nutrition assessment; Nutritional status; oesophageal; Patients; Symptom management; Tumors; undernutrition; Weight loss
• ISSN: 0952-3871; 1365-277X
• DOI: 10.1111/jhn.12588

Background Patients with oesophago‐gastric (OG) cancer may be at risk of malnutrition, troublesome gastrointestinal symptoms (GI) and reduced dietary intake in view of the tumour location and multimodality curative treatment approach. Longitudinal research is lacking. The present study aimed to assess (i) nutritional status and how it evolved over the first year; (ii) the association between nutritional status scores and GI symptom scores; and (iii) the nutrient and food group intake pattern. Methods This was a prospective, observational study of patients with an OG lesion planned for radical treatment, with assessment at diagnosis, 3 months and 12 months after the start of treatment. Nutritional assessment was performed using the Patient‐Generated Subjective Global Assessment, GI symptoms measured using the modified Gastrointestinal Symptom Rating Scale and dietary intake assessed using a semi‐quantitative food frequency approach. Results Eighty patients (61 males, 19 females; aged 46–89 years) were recruited. At baseline, 3 (n = 68) and 12 months (n = 57), 61%, 62% and 60%, respectively, were moderately/severely malnourished. Higher symptom burden was associated with poorer nutritional status at baseline (r = 0.55, P