Universal varicella vaccination increased the incidence of herpes zoster in the child-rearing generation as its short-term effect

•Miyazaki herpes zoster surveillance elucidated the effect of universal vaccination.•The number of herpes zoster patients increased 1.5 times from 1997 to 2016.•Universal varicella vaccination gradually reduced the number of varicella patients.•Universal vaccination increased herpes zoster incidence...

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Bibliographic Details
Published in:Journal of dermatological science 2018-10, Vol.92 (1), p.89-96
Main Authors: Toyama, Nozomu, Shiraki, Kimiyasu
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Chickenpox - epidemiology
Chickenpox - immunology
Chickenpox - prevention & control
Chickenpox - virology
Chickenpox Vaccine - administration & dosage
Child
Child Rearing
Child, Preschool
Child-rearing generation
Epidemiology
Female
Herpes zoster
Herpes Zoster - epidemiology
Herpes Zoster - immunology
Herpes Zoster - virology
Humans
Immunity
Incidence
Infant
Infant, Newborn
Japan - epidemiology
Male
Middle Aged
Time Factors
Universal vaccination
Vaccination
Varicella
Young Adult
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Summary:•Miyazaki herpes zoster surveillance elucidated the effect of universal vaccination.•The number of herpes zoster patients increased 1.5 times from 1997 to 2016.•Universal varicella vaccination gradually reduced the number of varicella patients.•Universal vaccination increased herpes zoster incidence in child-rearing generation.•Herpes zoster incidence increased in two years after universal varicella vaccination. Effects of universal varicella vaccination on the herpes zoster (HZ) incidence have not been elucidated. Universal varicella vaccination was introduced in Japan in October 2014. We investigated the effects of universal varicella vaccination on HZ epidemiology. Patients with HZ have been monitored by the Miyazaki Dermatologist Society since 1997, and the effects of universal vaccination on the HZ incidences have been analyzed to determine which generation is most affected. The number of HZ patients increased 1.54 times, and the gradual increase in the HZ incidence was observed in not only patients >60 years, but also other generations during the period from 1997 to 2017. The number of varicella patients was gradually reduced from 2010 to 2017 before introduction of universal varicella vaccination, and the HZ incidence in yearly change significantly increased from 2014 to 2016 in the total population associated with the significant decrease in varicella incidence. The HZ incidence significantly increased for individuals aged 20 to 49 years from 2014 to 2015 and most for individuals age 20–29 years (odds ratio [OR], 1.270; 95% confidence interval [CI], 1.071–1.505, P
ISSN:0923-1811
1873-569X
DOI:10.1016/j.jdermsci.2018.07.003