A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin

Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment o...

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Published in:Bone (New York, N.Y.) N.Y.), 2018-11, Vol.116, p.87-93
Main Authors: Simon, David, Kleyer, Arnd, Englbrecht, Matthias, Stemmler, Fabian, Simon, Christoph, Berlin, Andreas, Kocijan, Roland, Haschka, Judith, Hirschmann, Simon, Atreya, Raja, Neurath, Markus F., Sticherling, Michael, Rech, Juergen, Hueber, Axel J., Engelke, Klaus, Schett, Georg
Format: Article
Language:English
Subjects:
Arthritis
Bone and Bones - pathology
Bone Density
Case-Control Studies
Chronic Disease
Cohort Studies
Colitis
Gastrointestinal Tract - pathology
Humans
Inflammation - pathology
Inflammatory bone loss
Joints - pathology
Linear Models
Male
Middle Aged
Peripheral quantitative computed tomography
Psoriasis
Skin - pathology
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creator Simon, David
Kleyer, Arnd
Englbrecht, Matthias
Stemmler, Fabian
Simon, Christoph
Berlin, Andreas
Kocijan, Roland
Haschka, Judith
Hirschmann, Simon
Atreya, Raja
Neurath, Markus F.
Sticherling, Michael
Rech, Juergen
Hueber, Axel J.
Engelke, Klaus
Schett, Georg
description Chronic inflammatory diseases are associated with bone loss. While the occurrence of systemic bone loss is well described in chronic inflammatory diseases, the impact of these conditions on articular bone has not been systematically investigated. Recent refinements in high-resolution CT assessment of the joints now allow the accurate measure of articular bone composition. In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand. Metacarpal heads were assessed for total, trabecular and cortical volumetric bone mineral density (vBMD). Only ACPA+RA, but not the remaining inflammatory diseases (ACPA−RA, CD, UC, PsO, PsA) showed significant (p 
doi_str_mv 10.1016/j.bone.2018.07.017
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subjects Arthritis
Bone and Bones - pathology
Bone Density
Case-Control Studies
Chronic Disease
Cohort Studies
Colitis
Gastrointestinal Tract - pathology
Humans
Inflammation - pathology
Inflammatory bone loss
Joints - pathology
Linear Models
Male
Middle Aged
Peripheral quantitative computed tomography
Psoriasis
Skin - pathology
title A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin
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