Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?

Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&)‐stained s...

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Bibliographic Details
Published in:Histopathology 2019-01, Vol.74 (2), p.248-255
Main Authors: Xu, Xiaoli, Bi, Rui, Shui, Ruohong, Yu, Baohua, Cheng, Yufan, Tu, Xiaoyu, Yang, Wentao
Format: Article
Language:English
Subjects:
Breast
Epidermal growth factor
ErbB-2 protein
Fluorescence in situ hybridization
Gene amplification
Immunohistochemistry
Lymph nodes
Metastases
Metastasis
micropapillary
nuclear grade
Progesterone
prognosis
pure mucinous carcinoma
Statistical analysis
Tumors
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Summary:Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&)‐stained slides were reviewed, and clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological grade, lymph node (LN) status, immunohistochemistry (IHC) staining of hormone receptor, human epidermal growth factor receptor 2 (HER2) expression and Ki‐67 proliferation index were analysed. Fluorescence in‐situ hybridisation (FISH) was used to verify the amplification of the HER2 gene in IHC 2+ cases. Seventy‐one cases of PMC were followed‐up from 18 to 110 months (median = 68 months). All PMC patients were female, aged 31–83 years (median = 57 years). All PMCs were nuclear grades 1 or 2. Oestrogen receptor was positive in all cases (100%) and progesterone receptor was positive in 68 cases (90.7%). There was no 3+ staining or gene amplification of HER2. Four patients had axillary LN metastasis (5.7%). Micropapillae were observed in 60 cases (80%) with varied percentages, and divided into five groups: 0%,
ISSN:0309-0167
1365-2559
DOI:10.1111/his.13722