Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?

Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&)‐stained s...

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Published in:Histopathology 2019-01, Vol.74 (2), p.248-255
Main Authors: Xu, Xiaoli, Bi, Rui, Shui, Ruohong, Yu, Baohua, Cheng, Yufan, Tu, Xiaoyu, Yang, Wentao
Format: Article
Language:English
Subjects:
Breast
Epidermal growth factor
ErbB-2 protein
Fluorescence in situ hybridization
Gene amplification
Immunohistochemistry
Lymph nodes
Metastases
Metastasis
micropapillary
nuclear grade
Progesterone
prognosis
pure mucinous carcinoma
Statistical analysis
Tumors
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cited_by cdi_FETCH-LOGICAL-c3532-c16d0791a72b35dc34c05c6258273af91e922186c94843ed1608e33cfd9790243
cites cdi_FETCH-LOGICAL-c3532-c16d0791a72b35dc34c05c6258273af91e922186c94843ed1608e33cfd9790243
container_end_page 255
container_issue 2
container_start_page 248
container_title Histopathology
container_volume 74
creator Xu, Xiaoli
Bi, Rui
Shui, Ruohong
Yu, Baohua
Cheng, Yufan
Tu, Xiaoyu
Yang, Wentao
description Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&)‐stained slides were reviewed, and clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological grade, lymph node (LN) status, immunohistochemistry (IHC) staining of hormone receptor, human epidermal growth factor receptor 2 (HER2) expression and Ki‐67 proliferation index were analysed. Fluorescence in‐situ hybridisation (FISH) was used to verify the amplification of the HER2 gene in IHC 2+ cases. Seventy‐one cases of PMC were followed‐up from 18 to 110 months (median = 68 months). All PMC patients were female, aged 31–83 years (median = 57 years). All PMCs were nuclear grades 1 or 2. Oestrogen receptor was positive in all cases (100%) and progesterone receptor was positive in 68 cases (90.7%). There was no 3+ staining or gene amplification of HER2. Four patients had axillary LN metastasis (5.7%). Micropapillae were observed in 60 cases (80%) with varied percentages, and divided into five groups: 0%,
doi_str_mv 10.1111/his.13722
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In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&amp;)‐stained slides were reviewed, and clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological grade, lymph node (LN) status, immunohistochemistry (IHC) staining of hormone receptor, human epidermal growth factor receptor 2 (HER2) expression and Ki‐67 proliferation index were analysed. Fluorescence in‐situ hybridisation (FISH) was used to verify the amplification of the HER2 gene in IHC 2+ cases. Seventy‐one cases of PMC were followed‐up from 18 to 110 months (median = 68 months). All PMC patients were female, aged 31–83 years (median = 57 years). All PMCs were nuclear grades 1 or 2. Oestrogen receptor was positive in all cases (100%) and progesterone receptor was positive in 68 cases (90.7%). There was no 3+ staining or gene amplification of HER2. Four patients had axillary LN metastasis (5.7%). Micropapillae were observed in 60 cases (80%) with varied percentages, and divided into five groups: 0%, &lt;20%, 20–49%, 50–89% and ≥90%, with 15 (20%), 15 (20%), 17 (22.7%), 17 (22.7%) and 11 (14.7%) cases in each. Follow‐up results showed that neither recurrence nor distant metastasis occurred in all PMCs. Statistical analysis revealed that only larger tumour size was correlated significantly with LN metastasis (P &lt; 0.05). Conclusions The presence of nuclear grades 1 or 2 micropapillae, irrespective of the percentage, had no significant relationship with LN metastasis and patients’ survival of PMC.</description><identifier>ISSN: 0309-0167</identifier><identifier>EISSN: 1365-2559</identifier><identifier>DOI: 10.1111/his.13722</identifier><identifier>PMID: 30066338</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Breast ; Epidermal growth factor ; ErbB-2 protein ; Fluorescence in situ hybridization ; Gene amplification ; Immunohistochemistry ; Lymph nodes ; Metastases ; Metastasis ; micropapillary ; nuclear grade ; Progesterone ; prognosis ; pure mucinous carcinoma ; Statistical analysis ; Tumors</subject><ispartof>Histopathology, 2019-01, Vol.74 (2), p.248-255</ispartof><rights>2018 John Wiley &amp; Sons Ltd.</rights><rights>Copyright © 2019 John Wiley &amp; Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-c16d0791a72b35dc34c05c6258273af91e922186c94843ed1608e33cfd9790243</citedby><cites>FETCH-LOGICAL-c3532-c16d0791a72b35dc34c05c6258273af91e922186c94843ed1608e33cfd9790243</cites><orcidid>0000-0003-0495-1105 ; 0000-0001-9788-1534 ; 0000-0003-4433-4136</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30066338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Xiaoli</creatorcontrib><creatorcontrib>Bi, Rui</creatorcontrib><creatorcontrib>Shui, Ruohong</creatorcontrib><creatorcontrib>Yu, Baohua</creatorcontrib><creatorcontrib>Cheng, Yufan</creatorcontrib><creatorcontrib>Tu, Xiaoyu</creatorcontrib><creatorcontrib>Yang, Wentao</creatorcontrib><title>Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?</title><title>Histopathology</title><addtitle>Histopathology</addtitle><description>Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&amp;)‐stained slides were reviewed, and clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological grade, lymph node (LN) status, immunohistochemistry (IHC) staining of hormone receptor, human epidermal growth factor receptor 2 (HER2) expression and Ki‐67 proliferation index were analysed. Fluorescence in‐situ hybridisation (FISH) was used to verify the amplification of the HER2 gene in IHC 2+ cases. Seventy‐one cases of PMC were followed‐up from 18 to 110 months (median = 68 months). All PMC patients were female, aged 31–83 years (median = 57 years). All PMCs were nuclear grades 1 or 2. Oestrogen receptor was positive in all cases (100%) and progesterone receptor was positive in 68 cases (90.7%). There was no 3+ staining or gene amplification of HER2. Four patients had axillary LN metastasis (5.7%). Micropapillae were observed in 60 cases (80%) with varied percentages, and divided into five groups: 0%, &lt;20%, 20–49%, 50–89% and ≥90%, with 15 (20%), 15 (20%), 17 (22.7%), 17 (22.7%) and 11 (14.7%) cases in each. Follow‐up results showed that neither recurrence nor distant metastasis occurred in all PMCs. Statistical analysis revealed that only larger tumour size was correlated significantly with LN metastasis (P &lt; 0.05). Conclusions The presence of nuclear grades 1 or 2 micropapillae, irrespective of the percentage, had no significant relationship with LN metastasis and patients’ survival of PMC.</description><subject>Breast</subject><subject>Epidermal growth factor</subject><subject>ErbB-2 protein</subject><subject>Fluorescence in situ hybridization</subject><subject>Gene amplification</subject><subject>Immunohistochemistry</subject><subject>Lymph nodes</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>micropapillary</subject><subject>nuclear grade</subject><subject>Progesterone</subject><subject>prognosis</subject><subject>pure mucinous carcinoma</subject><subject>Statistical analysis</subject><subject>Tumors</subject><issn>0309-0167</issn><issn>1365-2559</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kLtOwzAUQC0EoqUw8APIEgsMaW3fOk4mhCqglUAMwMJiuY6jumoe2IlQN_6BP-RLcJvCgIQXezg-uvcgdErJkIYzWlg_pCAY20N9CjGPGOfpPuoTIGlEaCx66Mj7JSFUAGOHqAeExDFA0kevD1a7qla1Xa2UW-NaNY1xJbYlrltncNFqW1atx1q5zatQuMpxszB47ozyDf76-MRZZTy2DS62n3HlcFk1V8foIFcrb0529wC93N48T6bR_ePdbHJ9H2ngwCJN44yIlCrB5sAzDWNNuI4ZT5gAlafUpIzRJNbpOBmDyWhMEgOg8ywVKWFjGKCLzlu76q01vpGF9dqEfUoTJpeMJJRzJhIW0PM_6LJqXRmmk4zyoAMikkBddlQo470zuaydLUIdSYncBJchuNwGD-zZztjOC5P9kj-FAzDqgHe7Muv_TXI6e-qU36KriMI</recordid><startdate>201901</startdate><enddate>201901</enddate><creator>Xu, Xiaoli</creator><creator>Bi, Rui</creator><creator>Shui, Ruohong</creator><creator>Yu, Baohua</creator><creator>Cheng, Yufan</creator><creator>Tu, Xiaoyu</creator><creator>Yang, Wentao</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0495-1105</orcidid><orcidid>https://orcid.org/0000-0001-9788-1534</orcidid><orcidid>https://orcid.org/0000-0003-4433-4136</orcidid></search><sort><creationdate>201901</creationdate><title>Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?</title><author>Xu, Xiaoli ; Bi, Rui ; Shui, Ruohong ; Yu, Baohua ; Cheng, Yufan ; Tu, Xiaoyu ; Yang, Wentao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-c16d0791a72b35dc34c05c6258273af91e922186c94843ed1608e33cfd9790243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Breast</topic><topic>Epidermal growth factor</topic><topic>ErbB-2 protein</topic><topic>Fluorescence in situ hybridization</topic><topic>Gene amplification</topic><topic>Immunohistochemistry</topic><topic>Lymph nodes</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>micropapillary</topic><topic>nuclear grade</topic><topic>Progesterone</topic><topic>prognosis</topic><topic>pure mucinous carcinoma</topic><topic>Statistical analysis</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Xiaoli</creatorcontrib><creatorcontrib>Bi, Rui</creatorcontrib><creatorcontrib>Shui, Ruohong</creatorcontrib><creatorcontrib>Yu, Baohua</creatorcontrib><creatorcontrib>Cheng, Yufan</creatorcontrib><creatorcontrib>Tu, Xiaoyu</creatorcontrib><creatorcontrib>Yang, Wentao</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Histopathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Xiaoli</au><au>Bi, Rui</au><au>Shui, Ruohong</au><au>Yu, Baohua</au><au>Cheng, Yufan</au><au>Tu, Xiaoyu</au><au>Yang, Wentao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?</atitle><jtitle>Histopathology</jtitle><addtitle>Histopathology</addtitle><date>2019-01</date><risdate>2019</risdate><volume>74</volume><issue>2</issue><spage>248</spage><epage>255</epage><pages>248-255</pages><issn>0309-0167</issn><eissn>1365-2559</eissn><abstract>Aims Pure mucinous carcinoma (PMC) of the breast is a low‐grade cancer. In this study, we aimed to elucidate the prognostic significance of micropapillary structures in breast PMC. Methods and results Seventy‐five patients with breast PMC were recruited. All haematoxylin and eosin (H&amp;)‐stained slides were reviewed, and clinicopathological features including age, tumour size, growth pattern, nuclear grade, histological grade, lymph node (LN) status, immunohistochemistry (IHC) staining of hormone receptor, human epidermal growth factor receptor 2 (HER2) expression and Ki‐67 proliferation index were analysed. Fluorescence in‐situ hybridisation (FISH) was used to verify the amplification of the HER2 gene in IHC 2+ cases. Seventy‐one cases of PMC were followed‐up from 18 to 110 months (median = 68 months). All PMC patients were female, aged 31–83 years (median = 57 years). All PMCs were nuclear grades 1 or 2. Oestrogen receptor was positive in all cases (100%) and progesterone receptor was positive in 68 cases (90.7%). There was no 3+ staining or gene amplification of HER2. Four patients had axillary LN metastasis (5.7%). Micropapillae were observed in 60 cases (80%) with varied percentages, and divided into five groups: 0%, &lt;20%, 20–49%, 50–89% and ≥90%, with 15 (20%), 15 (20%), 17 (22.7%), 17 (22.7%) and 11 (14.7%) cases in each. Follow‐up results showed that neither recurrence nor distant metastasis occurred in all PMCs. Statistical analysis revealed that only larger tumour size was correlated significantly with LN metastasis (P &lt; 0.05). Conclusions The presence of nuclear grades 1 or 2 micropapillae, irrespective of the percentage, had no significant relationship with LN metastasis and patients’ survival of PMC.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30066338</pmid><doi>10.1111/his.13722</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-0495-1105</orcidid><orcidid>https://orcid.org/0000-0001-9788-1534</orcidid><orcidid>https://orcid.org/0000-0003-4433-4136</orcidid></addata></record>
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subjects Breast
Epidermal growth factor
ErbB-2 protein
Fluorescence in situ hybridization
Gene amplification
Immunohistochemistry
Lymph nodes
Metastases
Metastasis
micropapillary
nuclear grade
Progesterone
prognosis
pure mucinous carcinoma
Statistical analysis
Tumors
title Micropapillary pattern in pure mucinous carcinoma of the breast – does it matter or not?
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