Increased cardiac sympathetic nerve activity in ovine heart failure is reduced by lesion of the area postrema, but not lamina terminalis

Increased cardiac sympathetic nerve activity (CSNA) is a key feature of heart failure (HF) and is associated with poor outcome. There is evidence that central angiotensinergic mechanisms contribute to the increased CSNA in HF, but the central sites involved are unknown. In an ovine, rapid pacing mod...

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Bibliographic Details
Published in:Basic research in cardiology 2018-09, Vol.113 (5), p.35-11, Article 35
Main Authors: Abukar, Yonis, Ramchandra, Rohit, Hood, Sally G., McKinley, Michael J., Booth, Lindsea C., Yao, Song T., May, Clive N.
Format: Article
Language:English
Subjects:
Angiotensin
Angiotensin II Type 1 Receptor Blockers - administration & dosage
Animals
Area postrema
Area Postrema - physiopathology
Area Postrema - surgery
Arterial Pressure
Baroreceptors
Baroreflex
Brain stem
Bursts
Cardiology
Disease Models, Animal
Electrodes
Female
Heart
Heart - innervation
Heart diseases
Heart failure
Heart Failure - physiopathology
Heart Rate
Hypothalamus - physiopathology
Hypothalamus - surgery
Infusions, Intraventricular
Losartan - pharmacology
Medical materials
Medicine
Medicine & Public Health
Nausea
Neural Pathways - physiopathology
Original Contribution
Reflexes
Renin-Angiotensin System
Sheep
Sheep, Domestic
Sympathetic Nervous System - physiopathology
Tubes
Ventricle
Ventricles (cerebral)
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Summary:Increased cardiac sympathetic nerve activity (CSNA) is a key feature of heart failure (HF) and is associated with poor outcome. There is evidence that central angiotensinergic mechanisms contribute to the increased CSNA in HF, but the central sites involved are unknown. In an ovine, rapid pacing model of HF, we investigated the contribution of the lamina terminalis and area postrema to the increased CSNA and also the responses to fourth ventricular infusion of the angiotensin type 1 receptor antagonist losartan. Ablation of the area postrema or sham lesion ( n  = 6/group), placement of lamina terminalis lesion electrodes ( n  = 5), and insertion of a cannula into the fourth ventricle ( n  = 6) were performed when ejection fraction was ~ 50%. When ejection fraction was 
ISSN:0300-8428
1435-1803
DOI:10.1007/s00395-018-0695-9