MFG‐E8 reverses microglial‐induced neurotoxic astrocyte (A1) via NF‐κB and PI3K‐Akt pathways

Recent evidence have suggested that neuroinflammation and ischemia induce the activation of two different types of reactive astrocytes, termed A1 and A2. Additionally, A1 astrocytes contribute to the death of neurons and oligodendrocytes in neurodegenerative diseases, such as Alzheimer’s disease (AD...

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Bibliographic Details
Published in:Journal of cellular physiology 2019-01, Vol.234 (1), p.904-914
Main Authors: Xu, Xiaotian, Zhang, Aiwu, Zhu, Yingting, He, Wen, Di, Wei, Fang, Yannan, Shi, Xiaolei
Format: Article
Language:English
Subjects:
1-Phosphatidylinositol 3-kinase
AKT protein
Alzheimer's disease
astrocyte
Astrocytes
Aβ42
Complement activation
Conditioning
Epidermal growth factor
Growth factors
Inflammation
Interleukins
Ischemia
MFG‐E8
Microglia
Milk fat globule membranes
Neurodegenerative diseases
Neurological diseases
Neurotoxicity
Oligodendrocytes
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